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Browsing by Author "Ford, Nathan"

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AIDS-associated Kaposi's sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa

Author: Chu, Kathryn ; Mahlangeni, Gcina ; Swannet, Sarah ; Ford, Nathan ; Boulle, Andrew ; Van Cutsem, Gilles Date: 2010 BACKGROUND: AIDS-associated Kaposi's sarcoma is an important, life-threatening opportunistic infection among people living with HIV/AIDS in resource-limited settings. In western countries, the introduction of combination antiretroviral therapy ... Read more c b
Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe

Author: Bygrave, Helen ; Mtangirwa, Judith ; Ncube, Kwenzakwenkosi ; Ford, Nathan ; Kranzer, Katharina ; Munyaradzi, Dhodho Date: 2012 Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in ... Read more c b
Antiretroviral treatment outcomes from a nurse-driven, community-supported HIV/AIDS treatment programme in rural Lesotho: observational cohort assessment at two years

Author: Cohen, Rachel ; Lynch, Sharonann ; Bygrave, Helen ; Eggers, Evi ; Vlahakis, Natalie ; Hilderbrand, Katherine ; Knight, Louise ; Pillay, Prinitha ; Saranchuk, Peter ; Goemaere, Eric ; Makakole, Lipontso ; Ford, Nathan Date: 2009 INTRODUCTION:Lesotho has the third highest HIV prevalence in the world (an adult prevalence of 23.2%). Despite a lack of resources for health, the country has implemented state-of-the-art antiretroviral treatment guidelines, including early ... Read more c b
Cesarean section rates and indications in sub-Saharan Africa: a multi-country study from Medecins sans Frontieres

Author: Chu, Kathryn ; Cortier, Hilde ; Maldonado, Fernando ; Mashant, Tshiteng ; Ford, Nathan ; Trelles, Miguel Date: 2012 Objectives The World Health Organization considers Cesarean section rates of 5-15% to be the optimal range for targeted provision of this life saving intervention. However, access to safe Cesarean section in resource-limited settings is much ... Read more c b
CMV retinitis screening and treatment in a resource-poor setting: three-year experience from a primary care HIV/AIDS programme in Myanmar

Author: Tun, NiNi ; London, Nikolas ; Kyaw, Moe ; Smithuis, Frank ; Ford, Nathan ; Margolis, Todd ; Drew, W Lawrence ; Lewallen, Susan ; Heiden, David Date: 2011 BACKGROUND: Cytomegalovirus retinitis is a neglected disease in resource-poor settings, in part because of the perceived complexity of care and because ophthalmologists are rarely accessible. In this paper, we describe a pilot programme of ... Read more c b
Correcting for mortality among patients lost to follow up on antiretroviral therapy in South Africa: a cohort analysis

Author: Van Cutsem, Gilles ; Ford, Nathan ; Hildebrand, Katherine ; Goemaere, Eric ; Mathee, Shaheed ; Abrahams, Musaed ; Coetzee, David ; Boulle, Andrew Date: 2011 BACKGROUND: Loss to follow-up (LTF) challenges the reporting of antiretroviral treatment (ART) programmes, since it encompasses patients alive but lost to programme and deaths misclassified as LTF. We describe LTF before and after correction ... Read more c b
Density of healthcare providers and patient outcomes: evidence from a nationally representative multi-site HIV treatment program in Uganda

Author: Bakanda, Celestin ; Birungi, Josephine ; Mwesigwa, Robert ; Zhang, Wendy ; Hagopian, Amy ; Ford, Nathan ; Mills, Edward J Date: 2011 Objective We examined the association between density of healthcare providers and patient outcomes using a large nationally representative cohort of patients receiving combination antiretroviral therapy (cART) in Uganda. Design We obtained ... Read more c b
Does direct observation of antiretroviral therapy improve outcomes for HIV/AIDS patients compared to non-observed therapy?: A systematic review and meta-analysis of randomized-controlled trials

Author: Ford, Nathan Date: 2009 Highly active antiretroviral therapy (HAART) has dramatically affected the course of HIV disease, resulting in a significant reduction in AIDS-related morbidity and mortality in both developed and developing countries. Read more
Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohort

Author: Ford, Nathan ; Darder, Marta ; Spelman, Tim ; Maclean, Emi ; Mills, Edward ; Boulle, Andrew Date: 2010 Objective Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure. ... Read more c b
Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa

Author: Luque-Fernandez, Miguel Angel ; Cutsem, Gilles Van ; Goemaere, Eric ; Hilderbrand, Katherine ; Schomaker, Michael ; Mantangana, Nompumelelo ; Mathee, Shaheed ; Dubula, Vuyiseka ; Ford, Nathan ; Hernán, Miguel A Date: 2013 BACKGROUND: Innovative models of care are required to cope with the ever-increasing number of patients on antiretroviral therapy in the most affected countries. This study, in Khayelitsha, South Africa, evaluates the effectiveness of a ... Read more c b
The first decade of antiretroviral therapy in Africa

Author: Ford, Nathan ; Calmy, Alexandra ; Mills, Edward Date: 2011 The past decade has seen remarkable progress in increasing access to antiretroviral therapy in resource-limited settings. Early concerns about the cost and complexity of treatment were overcome thanks to the efforts of a global coalition of ... Read more c b
An integrated approach of community health worker support for HIV/AIDS and TB care in Angonia district, Mozambique

Author: Simon, Sandrine ; Chu, Kathryn ; Frieden, Marthe ; Candrinho, Baltazar ; Ford, Nathan ; Schneider, Helen ; Biot, Marc Date: 2009 BACKGROUND:The need to scale up treatment for HIV/AIDS has led to a revival in community health workers to help alleviate the health human resource crisis in sub-Saharan Africa. Community health workers have been employed in Mozambique since ... Read more c b
Keeping health staff healthy: evaluation of a workplace initiative to reduce morbidity and mortality from HIV/AIDS in Malawi

Author: Bemelmans, Marielle ; van den Akker, Thomas ; Pasulani, Olesi ; Tayub, Nabila ; Hermann, Katharina ; Mwagomba, Beatrice ; Jalasi, Winnie ; Chiomba, Harriet ; Ford, Nathan ; Philips, Mit Date: 2011 BACKGROUND: In Malawi, the dramatic shortage of human resources for health is negatively impacted by HIV-related morbidity and mortality among health workers and their relatives. Many staff find it difficult to access HIV care through regular ... Read more c b
Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda

Author: Mills, Edward ; Bakanda, Celestin ; Birungi, Josephine ; Chan, Keith ; Hogg, Robert ; Ford, Nathan ; Nachega, Jean ; Cooper, Curtis Date: 2011 BACKGROUND:Because men in Africa are less likely to access HIV/AIDS care than women, we aimed to determine if men have differing outcomes from women across a nationally representative sample of adult patients receiving combination antiretroviral ... Read more c b
Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis

Author: Ford, Nathan ; Hargreaves, Sally ; Shanks, Leslie Date: 2012 Introduction Sepsis is one of the leading causes of childhood mortality, yet controversy surrounds the current treatment approach. We conducted a systematic review to assess the evidence base for fluid resuscitation in the treatment of children ... Read more c b
Nevirapine-associated early hepatotoxicity: incidence, risk factors, and associated mortality in a primary care ART programme in South Africa

Author: Chu, Kathryn M ; Boulle, Andrew M ; Ford, Nathan ; Goemaere, Eric ; Asselman, Valerie ; Van Cutsem, Gilles Date: 2010 BACKGROUND: The majority of antiretroviral treatment programmes in sub-Saharan Africa are scaling up antiretroviral treatment using a fixed dose first-line antiretroviral regimen containing stavudine, lamivudine, and nevirapine. One of the ... Read more c b
Outcomes for efavirenz versus nevirapine-containing regimens for treatment of HIV-1 infection: a systematic review and meta-analysis

Author: Pillay, Prinitha ; Ford, Nathan ; Shubber, Zara ; Ferrand, Rashida A Date: 2013 Introduction There is conflicting evidence and practice regarding the use of the non-nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) and nevirapine (NVP) in first-line antiretroviral therapy (ART). METHODS: We systematically ... Read more c b
Priorities for developing countries in the global response to non-communicable diseases

Author: Maher, Dermot ; Ford, Nathan ; Unwin, Nigel Date: 2012 The growing global burden of non communicable diseases (NCDs) is now killing 36 million people each year and needs urgent and comprehensive action. This article provides an overview of key critical issues that need to be resolved to ensure ... Read more c b
Provision and continuation of antiretroviral therapy during acute conflict: the experience of MSF in Central African Republic and Yemen

Author: Ferreyra, Cecilia ; O’Brien, Daniel ; Alonso, Beatriz ; Al-Zomour, Abdulbasset ; Ford, Nathan Date: 02 Jul 2018 Background: Unstable settings present challenges for the effective provision of antiretroviral treatment (ART). In this paper, we summarize the experience and results of providing ART and implementing contingency plans during acute instability ... Read more
Renal safety of a tenofovir-containing first line regimen: experience from an antiretroviral cohort in rural Lesotho

Author: Bygrave, Helen ; Kranzer, Katharina ; Hilderbrand, Katherine ; Jouquet, Guillaume ; Goemaere, Eric ; Vlahakis, Nathalie ; Triviño, Laura ; Makakole, Lipontso ; Ford, Nathan Date: 2011 Introduction Current guidelines contraindicate TDF use when creatinine clearance (CrCl) falls below 50 ml/min. We report prevalence of abnormal renal function at baseline and factors associated with abnormal renal function from a community ... Read more c b

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