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Browsing by Author "Engel, Mark E"

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AFROStrep (SA): a surveillance system for group A streptococcal infection in South Africa

Author: Barth, Dylan Dominic Date: 2018 BACKGROUND AND AIMS OF THE THESIS: Group A β-haemolytic Streptococcus (GAS) also known as Streptococcus pyogenes, is responsible for a wide range of invasive and non-invasive GAS diseases. Prevalence and incidence data on GAS from developing ... Read more
The burden of antenatal heart disease in South Africa: a systematic review

Author: Watkins, David ; Sebitloane, Motshedisi ; Engel, Mark E ; Mayosi, Bongani Date: 2012 BACKGROUND: Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans. METHODS: We systematically ... Read more c b
Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: a systematic review and meta-analysis

Author: Wasserman, Sean ; Engel, Mark E ; Griesel, Rulan ; Mendelson, Marc Date: 09 Sep 2016 Abstract Background Seroprevalence data and clinical studies in children suggest that the burden of pneumocystis pneumonia (PCP) in Africa may be underestimated. We performed a systematic ... Read more
Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review

Author: Wasserman, Sean ; Engel, Mark E ; Mendelson, Marc Date: 2013 BACKGROUND: Reports from Africa have suggested that pneumocystis pneumonia (PCP) is a less important cause of morbidity than in the developed world. However, more recent studies have shown high seroprevalence rates of P. jirovecii in healthy ... Read more c b
Conducting a meta-ethnography of qualitative literature: Lessons learnt

Author: Atkins, Salla ; Lewin, Simon ; Smith, Helen ; Engel, Mark E ; Fretheim, Atle ; Volmink, Jimmy Date: 2008 BACKGROUND:Qualitative synthesis has become more commonplace in recent years. Meta-ethnography is one of several methods for synthesising qualitative research and is being used increasingly within health care research. However, many aspects ... Read more c b
Does direct observation of antiretroviral therapy improve outcomes for HIV/AIDS patients compared to non-observed therapy?: A systematic review and meta-analysis of randomized-controlled trials

Author: Ford, Nathan Date: 2009 Highly active antiretroviral therapy (HAART) has dramatically affected the course of HIV disease, resulting in a significant reduction in AIDS-related morbidity and mortality in both developed and developing countries. Read more
The effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town

Author: Barth, Dylan Dominic Date: 2013 Part A: is the research protocol which outlines the background and the process of this research. This study is a population-based observational study nested within the Groote Schuur Hospital (GSH) cohort of a global study, REMEDY which is a ... Read more
Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: No evidence for an association

Author: Barth, Dylan Dominic ; Zühlke, Liesl ; Joachim, Alexia ; Hoegger, Tyler ; Mayosi, Bongani M ; Engel, Mark E Date: 01 Jun 2015 Background: Lack of adherence to international normalised ratio (INR) monitoring in rheumatic heart disease (RHD) patients is a contributor to cardio-embolic complications. This population-based observational study investigated whether the ... Read more c b
The effectiveness of community-based rehabilitation for providing services to people with stroke with functional limitations and participation restriction : a systematic review and implications

Author: Naidoo, Lionel Edmund Date: 2010 We conducted a systematic review and meta-analysis of randomised and quasi-randomised trials to determine the effectiveness of community-based rehabilitation versus hospital/institution based rehabilitation in providing rehabilitative services ... Read more
Effectiveness of control measures to prevent occupational tuberculosis infection in health care workers: a systematic review

Author: Schmidt, Bey-Marrié ; Engel, Mark E ; Abdullahi, Leila ; Ehrlich, Rodney Date: 25 May 2018 Background A number of guideline documents have been published over the past decades on preventing occupational transmission of tuberculosis (TB) infection in health care workers (HCWs). However, direct evidence for the ... Read more
The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis

Author: Mnguni, Ayanda Trevor ; Engel, Mark E ; Borkum, Megan S ; Mayosi, Bongani M Date: 2015 BACKGROUND: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4% to 8% of cases. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a ubiquitous tetrapeptide with anti-fibrotic ... Read more c b
The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review

Author: Mnguni, Ayanda Trevor Date: 2015 Background: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4-8% of cases. N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP) is a ubiquitous tetrapeptide with antifibrotic properties ... Read more
The effects of parent training interventions on parental self-efficacy for parents with young children with an autism spectrum disorder or other developmental disabilities : a systematic review

Author: Hohlfeld, Ameer Steven-Jörg Date: 2016 Background: A leading research priority worldwide is the need to improve the lives of those with disabilities through the effective development of interventions that can be carried out by non-specialists. Recent research has indicated that ... Read more
Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease

Author: Musuku, John ; Lungu, Joyce C ; Machila, Elizabeth ; Jones, Catherine ; Colin, Laurence ; Schwaninger, Sherri ; Musonda, Patrick ; Tadmor, Brigitta ; Spector, Jonathan M ; Engel, Mark E ; Zühlke, Liesl J Date: 06 Jul 2017 Background: Prompt and appropriate treatment of streptococcal pharyngitis decreases the risk of acute rheumatic fever and rheumatic heart disease (RHD). Understanding public perceptions and behaviors related to sore throat is fundamental to ... Read more
Factors associated with patient and health system delay in diagnosis and commencement of treatment for pulmonary tuberculosis in the Middle East and North Africa (MENA): systematic review

Author: Eltayeb, Dalya Date: 2016 This MPH dissertation undertakes a systematic review on factors associated with patient and health system delay in diagnosing and commencing treatment for pulmonary tuberculosis in Middle East and North Africa (MENA). The dissertation is ... Read more
Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies

Author: Engel, Mark E ; Stander, Raphaella ; Vogel, Jonathan ; Adeyemo, Adebowale A ; Mayosi, Bongani M Date: 2011 BACKGROUND: Acute rheumatic fever is considered to be a heritable condition, but the magnitude of the genetic effect is unknown. The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance ... Read more c b
Health education interventions to raise awareness of rheumatic fever: a systematic review protocol

Author: Ramsey, Laura ; Watkins, Lauren ; Engel, Mark E Date: 2013 BACKGROUND:There is a significant global health burden associated with acute rheumatic fever (ARF) and rheumatic heart disease (RHD), especially in developing countries. ARF and RHD most often strike children and young adults living in ... Read more c b
Integrating the prevention and control of rheumatic heart disease into country health systems: a systemic review

Author: Abrams, Jessica Date: 2018 Part A is a research protocol which describes the background and proposed methodology of this systematic review. This section contains the details of quantitative and qualitative methods to be used when analysing rheumatic heart disease (RHD) ... Read more
Long term outcome and the validity of EuroSCORE II in native-valve surgery for active endocarditis in a South African cohort

Author: Koshy, Jithan Jacob Date: 2015 Infective endocarditis was initially described in the early 16th century and only methodically reviewed after the 19th century when Osler gave the drive to the Royal College of Physicians in 1885 through his contribution. The last 25 years ... Read more
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study

Author: Shaboodien, Gasnat ; Engel, Mark E ; Syed, Faisal ; Poulton, Joanna ; Badri, Motasim ; Mayosi, Bongani Date: 2009 BACKGROUND: The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10-12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. We hypothesized ... Read more c b

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