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Browsing by Author "Denti, Paolo"

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Characterizing population pharmacokinetic/pharmacodynamic relationships in pulmonary tuberculosis infected adults using nonlinear mixed effects modelling

Author: Smythe, Wynand Anton Date: 2016 This pharmacokinetic sub-study was nested within the phase-III OFLOTUB study investigating the shortening of tuberculosis treatment. A total of 343 adults enrolled in Benin, Guinea, Senegal, and South Africa were randomized to receive rifampicin, ... Read more
Correction to: Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauf, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 19 Mar 2021 An amendment to this paper has been published and can be accessed via the original article. Read more c b
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauff, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 06 Jan 2021 Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal ... Read more c b
Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in newly diagnosed pulmonary TB patients in Tanzania

Author: Denti, Paolo ; Jeremiah, Kidola ; Chigutsa, Emmanuel ; Faurholt-Jepsen, Daniel ; PrayGod, George ; Range, Nyagosya ; Castel, Sandra ; Wiesner, Lubbe ; Hagen, Christian Munch ; Christiansen, Michael Date: 2015 Exposure to lower-than-therapeutic levels of anti-tuberculosis drugs is likely to cause selection of resistant strains of Mycobacterium tuberculosis and treatment failure. The first-line anti-tuberculosis (TB) regimen consists of rifampicin, ... Read more c b
Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children

Author: Bienczak, Andrzej Marek Date: 2017 Efavirenz and nevirapine are the most widely used agents for treatment of HIV in children. Sources of variability in their pharmacokinetics and its association with virological outcome and adverse events in African children are poorly ... Read more
Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label, phase II clinical trial (SAEFRIF)

Author: Nabisere, Ruth ; Musaazi, Joseph ; Denti, Paolo ; Aber, Florence ; Lamorde, Mohammed ; Dooley, Kelly E ; Aarnoutse, Rob ; Sloan, Derek J ; Sekaggya-Wiltshire, Christine Date: 13 Feb 2020 Abstract Background Tuberculosis (TB) is a significant public health problem that causes substantial morbidity and mortality. Current first-line anti-TB chemotherapy, although very effective, has limitations including long-treatment ... Read more c b
Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations

Author: Gausi, Kamunkhwala Date: 2022 The global scale-up of tuberculosis treatment administered with antiretroviral therapy (ART) is the primary contributor to the 11 million averted deaths among individuals living with HIV observed between 2000 and 2019 in adults and children. ... Read more
Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment

Author: Abdelwahab, Mahmoud Tareq Date: 2021 Tuberculosis continues to claim millions of lives each year despite enormous efforts to control the epidemic over the past century. It remains the leading cause of death worldwide from a curable infectious disease. Tuberculosis is a significant ... Read more
Population pharmacokinetic modelling to address the gaps in knowledge of commonly used HIV and TB drugs in children

Author: Tikiso, Tjokosela Date: 2021 The epidemiology of HIV and TB are overlapping, particularly in sub-Saharan Africa, and TB infection remains common in HIV-positive children. The combined administration of anti-tubercular and antiretroviral therapies(ART) may lead to drug-drug ... Read more
Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment

Author: Chirehwa, Maxwell Tawanda Date: 2018 The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in TB/HIV coinfected patients recruited in two phase III clinical trials (61 patients in TB-HAART and 222 patients in RAFA study) were described using nonlinear ... Read more
The Next Generation Scientist program: capacity-building for future scientific leaders in low- and middle-income countries

Author: Pillai, Goonaseelan ; Chibale, Kelly ; Constable, Edwin C ; Keller, Akiko N ; Gutierrez, Marcelo M ; Mirza, Fareed ; Sengstag, Christian ; Masimirembwa, Collen ; Denti, Paolo ; Maartens, Gary ; Ramsay, Michèle ; Ogutu, Bernhards ; Makonnen, Eyasu ; Gordon, Richard ; Ferreira, Carlos G ; Goldbaum, Fernando A ; Degrave, Wim M S ; Spector, Jonathan ; Tadmor, Brigitta ; Kaiser, Hedwig J Date: 10 Oct 2018 Background Scientific and professional development opportunities for early career scientists in low- and middle- income countries (LMICs) are limited and not consistent. There is a disproportionately low number of biomedical ... Read more

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Browsing by Author "Denti, Paolo"

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