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Browsing by Author "Davids, Malika"

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High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South african patients with extensively drug-resistant tuberculosis

Author: Pietersen, Elize ; Peter, Jonny ; Streicher, Elizabeth ; Sirgel, Frik ; Rockwood, Neesha ; Mastrapa, Barbara ; Te Riele, Julian ; Davids, Malika ; van Helden, Paul ; Warren, Robin ; Dheda, Keertan Date: 2015 BACKGROUND: There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin ... Read more c b
HIV associated Lymphocytic Interstitial Pneumonia: a clinical, histological and radiographic study from an HIV endemic resource-poor setting

Author: van Zyl-Smit, Richard N ; Naidoo, Jashira ; Wainwright, Helen ; Said-Hartley, Quanita ; Davids, Malika ; Goodman, Hillel ; Rogers, Sean ; Dheda, Keertan Date: 22 Apr 2015 Background: There is a paucity of clinical and histopathological data about HIV-associated lymphocytic interstitial pneumonitis (LIP) in adults from HIV endemic settings. The role of Ebstein-Barr virus (EBV) in the pathogenesis remains ... Read more c b
Making HIV testing work at the point of care in South Africa: a qualitative study of diagnostic practices

Author: Engel, Nora ; Davids, Malika ; Blankvoort, Nadine ; Dheda, Keertan ; Pai, Nitika Pant ; Pai, Madhukar Date: 17 Jun 2017 Background: Point of care testing promises to reduce delays in diagnosing and initiating treatment for infectious diseases such as Human Immuno-deficiency Virus (HIV). In South Africa, decentralized HIV testing with rapid tests offers important ... Read more
Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities

Author: Lenders, Laura Mary Date: 2016 BACKGROUND: Tuberculosis (TB) remains out of control globally. Recent promising vaccine candidates have failed in clinical trials and host immunity in the lung remains poorly understood. Pathogenesis of pulmonary cavitation, the basis of TB ... Read more
A survey on use of rapid tests and tuberculosis diagnostic practices by primary health care providers in South Africa: implications for the development of new point-of-care tests

Author: Davids, Malika ; Dheda, Keertan ; Pai, Nitika Pant ; Cogill, Dolphina ; Pai, Madhukar ; Engel, Nora Date: 2015 BACKGROUND: Effective infectious disease control requires early diagnosis and treatment initiation. Point-of-care testing offers rapid turn-around-times, facilitating same day clinical management decisions. To maximize the benefits of such ... Read more c b
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa

Author: Pooran, Anil ; Pieterson, Elize ; Davids, Malika ; Theron, Grant ; Dheda, Keertan Date: 2013 BACKGROUND: Drug-resistant tuberculosis (DR-TB) is undermining TB control in South Africa. However, there are hardly any data about the cost of treating DR-TB in high burden settings despite such information being quintessential for the ... Read more c b

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Browsing by Author "Davids, Malika"

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