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Browsing by Author "Darby, Matthew G"

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A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis

Author: Nieuwenhuizen, Natalie E ; Meter, Jeanne M ; Horsnell, William G ; Hoving, J Claire ; Fick, Lizette ; Sharp, Michael F ; Darby, Matthew G ; Parihar, Suraj P ; Brombacher, Frank ; Lopata, Andreas L Date: 2013 Background: Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, ... Read more c b
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity

Author: Nyangahu, Donald D ; Lennard, Katie S ; Brown, Bryan P ; Darby, Matthew G ; Wendoh, Jerome M ; Havyarimana, Enock ; Smith, Peter ; Butcher, James ; Stintzi, Alain ; Mulder, Nicola ; Horsnell, William ; Jaspan, Heather B Date: 07 Jul 2018 Background: Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. ... Read more
The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

Author: López-Cervantes, Juan Pablo ; Lønnebotn, Marianne ; Jogi, Nils Oskar ; Calciano, Lucia ; Kuiper, Ingrid Nordeide ; Darby, Matthew G ; Dharmage, Shyamali C ; Gómez-Real, Francisco ; Hammer, Barbara ; Bertelsen, Randi Jacobsen ; Johannessen, Ane ; Würtz, Anne Mette Lund ; Mørkve Knudsen, Toril ; Koplin, Jennifer ; Pape, Kathrine ; Skulstad, Svein Magne ; Timm, Signe ; Tjalvin, Gro ; Krauss-Etschmann, Susanne ; Accordini, Simone ; Schlünssen, Vivi ; Kirkeleit, Jorunn ; Svanes, Cecilie Date: 01 Dec 2021 Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases ... Read more c b
IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection

Author: Horsnell, William G C ; Darby, Matthew G ; Hoving, Jennifer C ; Nieuwenhuizen, Natalie ; McSorley, Henry J ; Ndlovu, Hlumani ; Bobat, Saeeda ; Kimberg, Matti ; Kirstein, Frank ; Cutler, Anthony J Date: 2013 In this study, B cell function in protective TH2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific ... Read more c b
Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring

Author: Darby, Matthew G Date: 2016 In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting ... Read more
Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells

Author: Darby, Matthew G Date: 2012 Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function ... Read more

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Browsing by Author "Darby, Matthew G"

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