OpenUCT Home
→
Browsing by Author

Browsing by Author "Dalvie, Shareefa"

Now showing items 1-6 of 6

The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

Author: Dalvie, Shareefa ; Stein, Dan J ; Koenen, Karestan ; Cardenas, Valerie ; Cuzen, Natalie L ; Ramesar, Raj ; Fein, George ; Brooks, Samantha J Date: 16 Dec 2014 Background: Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life adversity, genetic ... Read more c b
Elucidating the genetic aetiology of Bipolar Disorder

Author: Engelbrecht, Hannah-Ruth Date: 2018 Introduction: Bipolar disorder (BD) is a debilitating mood disorder with substantial genetic contributions. However, while the existence of its heritability is well-established, the precise genetic components and mechanisms of BD remain ... Read more
Elucidation of bipolar disorder : a convergent approach using genetics and imaging

Author: Dalvie, Shareefa Date: 2011 The aims were to determine whether variants, within ten selected candidate genes, have an association with BPD and whether any relationship exists between these variants and brain imaging volumes in subjects with BPD. The objectives were to ... Read more
Genetic analysis of bipolar disorder and alcohol use disorder

Author: Dalvie, Shareefa Date: 2015 Background: Mental health disorders represent a major public health problem in most countries around the world. In South Africa, the lifetime prevalence of psychiatric disorders is 30.3%, with substance-use disorders and mood disorders being ... Read more
Investigation of the Shared Genetic Influences on Bipolar Disorder, Borderline Personality Disorder and Regional Brain Structures

Author: Campbell, Megan Date: 2021 Background: The heritabilities of bipolar disorder (BD) and borderline personality disorder (BPD) are 80% and 65%, respectively, indicating substantial genetic contributions to both disorders. BD and BPD are often comorbid, and both disorders ... Read more
Novel CYP2E1 haplotype identified in a South African cohort

Author: Heathfield, Laura J ; Dalvie, Shareefa ; Kalideen, Kusha ; Dandara, Collet Date: 2014 Alcohol abuse accounts for approximately 2.5 million deaths annually and is the third highest risk factor for disease and disability. Alcohol is metabolised by polymorphic enzymes and the status of an individual with respect to alcohol ... Read more