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Browsing by Author "Churchyard, Gavin"

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Continued follow-up of Phambili Phase 2b randomized HIV-1 vaccine trial participants supports increased HIV-1 acquisition among vaccinated men

Author: Moodie, Zoe ; Metch, Barbara ; Bekker, Linda-Gail ; Churchyard, Gavin ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Laher, Fatima ; Roux, Surita ; Mngadi, Kathryn ; Innes, Craig Date: 2015 BACKGROUND: The Phase 2b double-blinded, randomized Phambili/HVTN 503 trial evaluated safety and efficacy of the MRK Ad5 gag / pol / nef subtype B HIV-1 preventive vaccine vs placebo in sexually active HIV-1 seronegative participants in South ... Read more c b
A cross-sectional study on the quality of life in HIV infected goldminers on highly active antiretroviral therapy in an industrial setting in South Africa

Author: Mngadi, Kathryn Therese Date: 2005 This study set out to document quality of life in the industrialized setting of HIV infected South African gold minders who are on highly-active anti-retroviral therapy, by administering the MOS SF-36, and to determine which categorical ... Read more
Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef vaccine Induced immune responses

Author: Hopkins, Kathryn L ; Laher, Fatima ; Otwombe, Kennedy ; Churchyard, Gavin ; Bekker, Linda-Gail ; DeRosa, Stephen ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Kublin, James ; Gray, Glenda Date: 2014 BACKGROUND: Phambili, the Merck (MRK)-Adenovirus Type 5 (Ad5) HIV-1 gag/pol/nef subtype B vaccine study, conducted in South Africa, suspended enrollment and vaccination when companion study, Step, was found non-efficacious. Although the vaccine ... Read more c b
Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa

Author: Knight, Dave ; Ehrlich, Rodney ; Cois, Annibale ; Fielding, Katherine ; Grant, Alison D ; Churchyard, Gavin Date: 01 Jun 2020 Background The stated intention to eliminate silicosis from the South African goldmining industry as well as current programmes to find and compensate ex-miners with silicosis require an understanding of variation in silicosis prevalence ... Read more c b
Risk factors for poor virological outcome at 12 months in a workplace-based antiretroviral therapy programme in South Africa: A cohort study

Author: Fielding, Katherine ; Charalambous, Salome ; Stenson, Amy ; Pemba, Lindiwe ; Martin, Des ; Wood, Robin ; Churchyard, Gavin ; Grant, Alison Date: 2008 BACKGROUND: Reasons for the variation in reported treatment outcomes from antiretroviral therapy (ART) programmes in developing countries are not clearly defined. METHODS: Among ART-naive individuals in a workplace ART programme in South ... Read more c b
Sequential Immunization with gp140 boosts immune responses primed by modified vaccinia Ankara or DNA in HIV-uninfected South African participants

Author: Churchyard, Gavin ; Mlisana, Koleka ; Karuna, Shelly ; Williamson, Anna-Lise ; Williamson, Carolyn ; Morris, Lynn ; Tomaras, Georgia D ; De Rosa, Stephen C ; Gilbert, Peter B ; Gu, Niya ; Yu, Chenchen ; Mkhize, Nonhlanhla N ; Hermanus, Tandile ; Allen, Mary ; Pensiero, Michael ; Barnett, Susan W ; Gray, Glenda ; Bekker, Linda-Gail ; Montefiori, David C ; Kublin, James ; Corey, Lawrence Date: 2016 BACKGROUND: The safety and immunogenicity of SAAVI DNA-C2 (4 mg IM), SAAVI MVA-C (2.9 x 10 9 pfu IM) and Novartis V2-deleted subtype C gp140 (100 mcg) with MF59 adjuvant in various vaccination regimens was evaluated in HIV-uninfected adults ... Read more c b
Uptake of genital mucosal sampling in HVTN 097, a phase 1b HIV vaccine trial in South Africa

Author: Lazarus, Erica Maxine ; Otwombe, Kennedy ; Adonis, Tania ; Sebastian, Elaine ; Gray, Glenda ; Grunenberg, Nicole ; Roux, Surita ; Churchyard, Gavin ; Innes, Craig ; Laher, Fatima Date: 2014 Because sexual transmission of HIV occurs across mucosal membranes, understanding the immune responses of the genital mucosa to vaccines may contribute knowledge to finding an effective candidate HIV vaccine. We describe the uptake of rectal ... Read more c b

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Browsing by Author "Churchyard, Gavin"

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