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Browsing by Author "Chege, Gerald"

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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag

Author: Jongwe, Tsungai Ivai Date: 2015 Of the 35 million people living with HIV-1 globally, approximately 71.4% are in the resource-limited sub-Saharan Africa. The immense sequence diversity of HIV-1, even within subtypes, makes it challenging to develop effective vaccines that ... Read more
Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak

Author: Chege, Gerald ; Warren, Robin ; van Pittius, Nico ; Burgers, Wendy ; Wilkinson, Robert ; Shephard, Enid ; Williamson, Anna-Lise Date: 2008 BACKGROUND:Both tuberculous and non-tuberculous mycobacteria can cause infection in nonhuman primates (NHP), indicating the existence of potential zoonotic transmission between these animals and visitors to zoos or animal handlers in primate ... Read more c b
HIV-1 subtype C mosaic Gag expressed by BCG and MVA elicits persistent effector t cell responses in a prime-boost regimen in mice

Author: Jongwe, Tsungai Ivai ; Chapman, Ros ; Douglass, Nicola ; Chetty, Shivan ; Chege, Gerald ; Williamson, Anna-Lise Date: 2016 Over 90% of HIV/AIDS positive individuals in sub-Saharan Africa are infected with highly heterogeneous HIV-1 subtype C (HIV-1C) viruses. One of the best ways to reduce the burden of this disease is the development of an affordable and effective ... Read more c b
An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines

Author: Singh, Vedantha Date: 2013 Previous studies from the HIV Vaccine Development Group at the University of Cape Town have reported that immunisation with recombinant modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on ... Read more

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