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Browsing by Author "Burgers, Wendy"

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Anti-vector immune responses to an MVA vaccine

Author: Muller, Tracey Date: 2011 This study characterised the humoral and cellular immune responses to MVA from a candidate MVA-vectored HIV vaccine in non-human primates, and examined the effect of anti-vector immunity on the response to the HIV immunogens. Read more
Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

Author: Tongo, Marcel ; Martin, Darren ; Zembe, Lycias ; Mpoudi-Ngole, Eitel ; Williamson, Carolyn ; Burgers, Wendy Date: 2013 BACKGROUND: Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV ... Read more c b
Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak

Author: Chege, Gerald ; Warren, Robin ; van Pittius, Nico ; Burgers, Wendy ; Wilkinson, Robert ; Shephard, Enid ; Williamson, Anna-Lise Date: 2008 BACKGROUND:Both tuberculous and non-tuberculous mycobacteria can cause infection in nonhuman primates (NHP), indicating the existence of potential zoonotic transmission between these animals and visitors to zoos or animal handlers in primate ... Read more c b
Development of a polychromatic flow cytometry panel for the evaluation of HIV-specific T cell responses

Author: Naicker, Prinola Date: 2009 Investigating T cell responses in HIV infection has revealed several correlates of viral control, but their importance is not fully understood. Further studies to understand the relationship between HIV and the immune system are warranted. ... Read more
Immunology and virology of HIV-1 infection in Cameroon

Author: Tongo Passo, Aime Marcel Simon Date: 2014 This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed ... Read more
Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa

Author: Zembe, Lycias Date: 2007 The increasing diversity of HIV-1 in different geographic regions presents a challenge for the development of an HIV/AIDS vaccine. Even if proven effective, the ability of a vaccine to have cross-subtype and intra-subtype protection remains ... Read more
Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa: implications for HIV vaccine design

Author: Zembe, Lycias Date: 2012 Background An effective HIV vaccine remains the main hope for controlling the HIV epidemic and is a global health priority. The genetic diversity of the virus across the globe is a major impediment to developing an effective vaccine. Whether ... Read more
Investigating defects in monocyte responses to Mycobacterium tuberculosis in HIV-TB co-infection

Author: Thawer, Narjis Khatoon G Date: 2014 Includes abstract. Includes bibliographical references. Read more
Phenotypic and functional characterisation of cervical and peripheral HIV-1 specific T cell responses

Author: Liebenberg, Lenine Julie Date: 2007 Distinct HIV variants occur at the genital mucosa compared to in blood, which may similarly result in differences in HIV T cell responses. There have been no studies of the maturational status of HIV-specific T cells present at the female ... Read more
Studies on immunity in the male genital tract

Author: Olivier, Abraham Jacobus Date: 2011 The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published ... Read more