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Browsing by Author "Brombacher, Frank"

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BALB/c mice deficient in CD4 T cell IL-4Rα expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype

Author: Bryson, Karen J ; Millington, Owain R ; Mokgethi, Thabang ; McGachy, H Adrienne ; Brombacher, Frank ; Alexander, James Date: 2011 Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4Rα-deficient mice fail to develop lesions and develop a ... Read more c b
A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis

Author: Nieuwenhuizen, Natalie E ; Meter, Jeanne M ; Horsnell, William G ; Hoving, J Claire ; Fick, Lizette ; Sharp, Michael F ; Darby, Matthew G ; Parihar, Suraj P ; Brombacher, Frank ; Lopata, Andreas L Date: 2013 Background: Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, ... Read more c b
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

Author: Horsnell, William G C ; Cutler, Antony J ; Hoving, J Claire ; Mearns, Helen ; Myburgh, Elmarie ; Arendse, Berenice ; Finkelman, Fred D ; Owens, Gary K ; Erle, Dave ; Brombacher, Frank Date: 2007 Interleukin 4 receptor α (IL-4Rα) is essential for effective clearance of gastrointestinal nematode infections. Smooth muscle cells are considered to play a role in the type 2 immune response-driven expulsion of gastrointestinal nematodes. ... Read more c b
Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection

Author: Hurdayal, Ramona Date: 2013 In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor ... Read more
Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection

Author: Hurdayal, Ramona ; Nieuwenhuizen, Natalie E ; Revaz-Breton, Mélanie ; Smith, Liezel ; Hoving, Jennifer C ; Parihar, Suraj P ; Reizis, Boris ; Brombacher, Frank Date: 2013 In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor ... Read more c b
Dendritic cell-mediated vaccination relies on interleukin-4 receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice

Author: Masic, Anita ; Hurdayal, Ramona ; Nieuwenhuizen, Natalie E ; Brombacher, Frank ; Moll, Heidrun Date: 2012 Prevention of tissue damages at the site of Leishmania major inoculation can be achieved if the BALB/c mice are systemically given L. major antigen (LmAg)-loaded bone marrow-derived dendritic cells (DC) that had been exposed to CpG-containing ... Read more c b
Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection

Author: Barkhuizen, Mark Date: 2008 African trypanosomiasis encompasses diseases caused by pathogenic trypanosomes, infecting both humans and animals alike. To determine the immunological role of IL=12 family members in Trypanosoma brucei brucei, Trypanosoma evansi and Trypanosoma ... Read more
The function of IL-4Rα expression on key immune cells during experimental Nippostrongylus brasiliensis infections

Author: Mearns, Helen Date: 2006 The lifecycle of the parasitic nematode Nippostrogylus brasiliensis resembles that of the human hookworms Necator americanus and Ancylostoma duodenale and as such is a useful murine model for studying hookworm disease. Read more
Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery

Author: Naidoo, Jerolen Date: Human Immunodeficiency Virus (HIV) is the causative agent of AIDS, a disease which affects over 24 million people globally and for which there is neither curative treatment nor vaccine available. As an intracellular pathogen that encodes only ... Read more
Genome-wide profiling of transcribed enhancers during macrophage activation

Author: Denisenko, Elena ; Guler, Reto ; Mhlanga, Musa M ; Suzuki, Harukazu ; Brombacher, Frank ; Schmeier, Sebastian Date: 23 Oct 2017 Background: Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and ... Read more
High throughput RNA interference based screen for the identification of genes implicated in listeria monocytogenes infection

Author: Tantoh, Asongwe Lionel Ateh Date: 2014 The facultative intracellular pathogen L. monocytogenes has acquired a versatile arsenal of adaptor proteins. It uses these proteins to invade and undermine the host immune surveillance system, as well as to survive and propagate within the ... Read more
Identification of genes involved in macrophage activation and effector functions against intracellular pathogens

Author: Schwegmann, Anita Ruth Date: 2006 This dissertation addressed the hypothesis that macrophages have an alternative killing mechanism that is independent of superoxide and nitric oxide but dependent on IFN-γ, TNF and C/EBPβ. Since the mechanism and the genes involved in this ... Read more
IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection

Author: Grahnert, Andreas ; Richter, Tina ; Piehler, Daniel ; Eschke, Maria ; Schulze, Bianca ; Müller, Uwe ; Protschka, Martina ; Köhler, Gabriele ; Sabat, Robert ; Brombacher, Frank ; Alber, Gottfried Date: 2014 Cryptococcus neoformans is an opportunistic fungal pathogen that causes lung inflammation and meningoencephalitis in immunocompromised people. Previously we showed that mice succumb to intranasal infection by induction of pulmonary interleukin ... Read more c b
IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

Author: Marillier, Reece ; Michels, Chesney ; Smith, Elizabeth ; Fick, Lizette ; Leeto, Mosiuoa ; Dewals, Benjamin ; Horsnell, William ; Brombacher, Frank Date: 2008 BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is ... Read more c b
IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis

Author: Gcanga, Lona Date: 2020 Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to current ... Read more
IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Author: Guler, Reto ; Parihar, Suraj P ; Savvi, Suzana ; Logan, Erin ; Schwegmann, Anita ; Roy, Sugata ; Nieuwenhuizen, Natalie E ; Ozturk, Mumin ; Schmeier, Sebastian ; Suzuki, Harukazu ; Brombacher, Frank Date: 2015 Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis ( Mtb ) infection. Evidence suggests that IL-4/IL-13 alternatively activated macrophages (aaMph or M2) are exploited by Mtb ... Read more c b
IL-4Rα-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness

Author: Dewals, Benjamin G ; Marillier, Reece G ; Hoving, Jennifer C ; Leeto, Mosiuoa ; Schwegmann, Anita ; Brombacher, Frank Date: 2010 IL-4Rα-dependent responses are essential for granuloma formation and host survival during acute schistosomiasis. Previously, we demonstrated that mice deficient for macrophage-specific IL-4Rα (LysMcreIl4ra−/lox) developed increased hepatotoxicity ... Read more c b
Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha

Author: Nieuwenhuizen, Natalie Date: 2007 The fish-parasitizing nematode Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses ... Read more
Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine

Author: Musaigwa, Fungai Date: 2022 Schistosomiasis is a devastating and neglected tropical disease caused by Schistosoma spp. parasites. The disease remains greatly neglected by global health control programmes thus classified as a top neglected tropical disease of humankind. ... Read more
Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4 (+) T cell responses

Author: Ndlovu, Hlumani ; Darby, Mathew ; Froelich, Monika ; Horsnell, William ; Lühder, Fred ; Hünig, Thomas ; Brombacher, Frank Date: 2014 IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing ... Read more c b

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