Browsing by Author "Bredell, Helba"

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HIV type 1 subtype C gag and nef diversity in Southern Africa.

Author: Bredell, Helba ; Martin, Darren P ; Van Harmelen Joanne ; Varsani, Arvind ; Sheppard, Haynes W ; Donovan, R ; Gray, C ; HIVNET028 Study Team ; Williamson, C Date: 2007 Several HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess ... Read more
Intra-and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials

Author: Zembe, Lycias ; Burgers, Wendy A ; Jaspan, Heather B ; Bekker, Linda-Gail ; Bredell, Helba ; Stevens, Gwynneth ; Gilmour, Jill ; Cox, Josephine H ; Fast, Patricia ; Hayes, Peter Date: 2011 The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell epitopes across different HIV clades. To ... Read more c b

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