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Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report : a prospective cohort study

Author: Davies, Mary-Ann Date: 2010 Excellent adherence to antiretroviral therapy (ART) is necessary if HIV-infected children are to experience the dramatically improved outcomes that this treatment affords. However, there is very limited data on adherence to antiretroviral ... Read more
Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study

Author: Davies, Mary-Ann ; Boulle, Andrew ; Fakir, Tanzeem ; Nuttall, James ; Eley, Brian Date: 2008 BACKGROUND:Antiretroviral therapy (ART) dramatically improves outcomes for children in Africa; however excellent adherence is required for treatment success. This study describes the utility of different measures of adherence in detecting ... Read more c b
Adjusting mortality for loss to follow-up: analysis of five ART programmes in sub-Saharan Africa

Author: Brinkhof, Martin W G ; Spycher, Ben D ; Yiannoutsos, Constantin ; Weigel, Ralf ; Wood, Robin ; Messou, Eugène ; Boulle, Andrew ; Egger, Matthias ; Sterne, Jonathan A C ; (IeDEA), for the International epidemiological Database to Evaluate AIDS Date: 2010 BACKGROUND: Evaluation of antiretroviral treatment (ART) programmes in sub-Saharan Africa is difficult because many patients are lost to follow-up. Outcomes in these patients are generally unknown but studies tracing patients have shown ... Read more c b
AIDS-associated Kaposi's sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa

Author: Chu, Kathryn ; Mahlangeni, Gcina ; Swannet, Sarah ; Ford, Nathan ; Boulle, Andrew ; Van Cutsem, Gilles Date: 2010 BACKGROUND: AIDS-associated Kaposi's sarcoma is an important, life-threatening opportunistic infection among people living with HIV/AIDS in resource-limited settings. In western countries, the introduction of combination antiretroviral therapy ... Read more c b
Associations of severe hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral theraphy

Author: Osler, Meg Date: 2007 Severe symptomatic hyperlactataemia and lactic acidosis (SHLA) are life-threatening events that are occurring at increasing incidence levels in South Africa. Globally, the rise in SHLA cases is closely correlated to the increased accessibility ... Read more
Baseline prevalence and incidence and risk factors for new-onset drug induced hearing loss in adults receiving drug-resistant tuberculosis (DR-TB) treatment in Khayelitsha, South Africa

Author: Njuguna, Christine Wanjiku Date: 2013 Treatment for drug-resistant tuberculosis (DR-TB) is longer and associated with more significant side-effects than drug susceptible TB. Second line injectable therapy using kanamycin, amikacin or capreomycin is associated with irreversible ... Read more
C-reactive protein and procalcitonin to discriminate between tuberculosis, Pneumocystis jirovecii pneumonia, and bacterial pneumonia in HIV-infected inpatients meeting WHO criteria for seriously ill: a prospective cohort study

Author: Mendelson, Fiona ; Griesel, Rulan ; Tiffin, Nicki ; Rangaka, Molebogeng ; Boulle, Andrew ; Mendelson, Marc ; Maartens, Gary Date: 14 Aug 2018 Background Tuberculosis, bacterial community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the three commonest causes of hospitalisation in HIV-infected adults. Prompt diagnosis and treatment ... Read more
Central nervous system disorders afrer starting antiretroviral therapy in South Africa

Author: Asselman, Valerie ; Thienemann, Fredrich ; Pepper, Dominique J ; Boulle, Andrew ; Wilkinson, Robert J ; Graeme Meintjes ; Marais, Suzaan Date: 2010 Objective: To describe the spectrum of central nervous system (CNS) disease during the first year of antiretroviral therapy (ART), and to determine the contribution of neurological immune reconstitution inflammatory syndrome (IRIS). Design: ... Read more
Child-headed households in South Africa: A statistical brief 2009

Author: Meintjes, Helen ; Hall, Katharine ; Marera, Double-Hugh ; Boulle, Andrew Date: 2009 Read more c b n d
A comparison of death recording by health centres and civil registration in South Africans receiving antiretroviral treatment

Author: Johnson, Leigh F ; Dorrington, Rob E ; Laubscher, Ria ; Hoffmann, Christopher J ; Wood, Robin ; Fox, Matthew P ; Cornell, Morna ; Schomaker, Michael ; Prozesky, Hans ; Tanser, Frank ; Davies, Mary-Ann ; Boulle, Andrew Date: 16 Dec 2015 Introduction: There is uncertainty regarding the completeness of death recording by civil registration and by health centres in South Africa. This paper aims to compare death recording by the two systems, in cohorts of South African patients ... Read more c b
Correcting for mortality among patients lost to follow up on antiretroviral therapy in South Africa: a cohort analysis

Author: Van Cutsem, Gilles ; Ford, Nathan ; Hildebrand, Katherine ; Goemaere, Eric ; Mathee, Shaheed ; Abrahams, Musaed ; Coetzee, David ; Boulle, Andrew Date: 2011 BACKGROUND: Loss to follow-up (LTF) challenges the reporting of antiretroviral treatment (ART) programmes, since it encompasses patients alive but lost to programme and deaths misclassified as LTF. We describe LTF before and after correction ... Read more c b
The cost, cause and place of death in patients dying with HIV/AIDS and who have access to ART

Author: Hellström, Lize Date: 2005 The study aimed to explore the causes of death, the costs involved in these deaths as well as the places where these deaths occurred. As all patients had access to ART once registered with the disease management company, AfA, most patients ... Read more
The cost-effectiveness of Antiretroviral Treatment in Khayelitsha, South Africa - a primary data analysis

Author: Cleary, Susan ; McIntyre, Di ; Boulle, Andrew Date: 2006 BACKGROUND:Given the size of the HIV epidemic in South Africa and other developing countries, scaling up antiretroviral treatment (ART) represents one of the key public health challenges of the next decade. Appropriate priority setting and ... Read more c b
Diagnostic accuracy of C-reactive protein and procalcitonin, compared with composite reference standards, to discriminate between tuberculosis, Pneumocystis jirovecii pneumonia and bacterial pneumonia in HIV-infected inpatients meeting WHO criteria for seriously ill

Author: Mendelson, Fiona Date: 2018 Tuberculosis, bacterial community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the commonest causes of hospitalisation in HIV-infected individuals. Prompt diagnosis and treatment initiation are important to reduce ... Read more
Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohort

Author: Ford, Nathan ; Darder, Marta ; Spelman, Tim ; Maclean, Emi ; Mills, Edward ; Boulle, Andrew Date: 2010 Objective Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure. ... Read more c b
The effeciveness and determinants of effectiveness of antiretroviral therapy for adults in the Western Cape Province, South Africa

Author: Boulle, Andrew Date: 2009 Antiretroviral therapy (ART) first became available in the public sector in the Western Cape Province in Khayelitsha in 2001. This thesis describes the effectiveness of ART in Khayelitsha and the Province, following adult patients for up to ... Read more
Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa

Author: Coetzee, David ; Hilderbrand, Katherine ; Boulle, Andrew ; Draper, Beverley ; Abdullah, Fareed ; Goemaere, Eric Date: 2005 Objective: The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict ... Read more
Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial

Author: Allen, Elizabeth Date: 2008 [Background and rationale] Malaria accounts for a large public health burden in Mozambique and a treatment policy with effective anti-malarials is a key component of their malaria control programme. Artemisinin-based combination therapies ... Read more
Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial

Author: Allen, Elizabeth N ; Little, Francesca ; Camba, Tunisio ; Cassam, Yasmin ; Raman, Jaishree ; Boulle, Andrew ; Barnes, Karen I Date: 2009 BACKGROUND: An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique. METHODS: Between 2003 and 2005, ... Read more c b
Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009

Author: Luque-Fernandez, Miguel Angel ; Schomaker, Michael ; Mason, Peter ; Fesselet, Jean ; Baudot, Yves ; Boulle, Andrew ; Maes, Peter Date: 2012 BACKGROUND: In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage ... Read more c b

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