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Browsing by Author "Blackburn, Jonathan"

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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers

Author: Smith, Muneerah Date: 2018 Cancer is a heterogenous disease capable of forming and spreading in most tissues of the human body. Cancer screening and diagnosis can be performed through medical procedures, which are highly invasive, requiring an intensive infrastructure. ... Read more
Analysis of urinary lipid biomarker candidates from tuberculosis patients by multiple reaction monitoring

Author: Waldron, Elizabeth Louise Date: 2019 Background: Tuberculosis (TB) is an aggressive disease and is the leading cause of death by infectious disease in South Africa. With early diagnosis and correct treatment, almost all TB cases can be cured. The main diagnostic tests in South ... Read more
A bioinformatic study on the feasibility of a cross-species proteomics analyses of mycobacteria

Author: Rajaonarifara, Elinambinina Date: 2013 Includes abstract. Includes bibliographical references. Read more
Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors

Author: Seele, Palesa Pamela Date: 2019 Cavitation is a key facilitator in transmission of Mycobacterium tuberculosis (M. tb). Upregulation of matrix metalloproteases (MMPs) has been documented in patients with tuberculosis (TB), while their tissue inhibitor (TIMPs) levels remained ... Read more
The characterisation of the peanut agglutinin an evolved plant lectin, with improved specificity to the Thompson Freidenriech antigen

Author: Lagardien, Zaida Date: 2013 Peanut agglutinin (PNA), a carbohydrate binding protein, is able to recognise and bind a number of distinct carbohydrate structures that have been implicated in a number of disease pathologies in humans. In vitro studies of PNA have previously ... Read more
Comprehensive proteomic profiling of clinically relevant strains of Mycobacterium tuberculosis

Author: Peters, Julian S Date: 2014 Tuberculosis is an airborne infectious disease caused by the bacillus known as Mycobacterium tuberculosis. Despite limited genetic variability, Mycobacterium tuberculosis strains exhibit vast discrepancies in phenotypic presentation in terms ... Read more
Development of computational methods for custom protein arrays analysis : a case study on a 100-protein ("CT100") cancer/testis antigen array

Author: Safari Serufuri, Jean-Michel Date: 2010 Custom antigen arrays offer a platform to assay the serological response of cancer patients to at set of selected cancer testis antigens in order to infer a diagnosis value or to assess the patient responses to particular treatments. However, ... Read more
Differential Lipidomic and Proteomic Responses Induced by Sub-lethal Drug Challenge in Susceptible and Drug Resistant Mycobacterium smegmatis

Author: Giddey, Alexander D Date: 2021 Tuberculosis remains a major global health challenge and the increasing strength and prevalence of drug resistance threaten to undo much of the good progress made. As one of the primary, frontline anti-tuberculous drugs, growing resistance ... Read more
Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis

Author: Peyper, Janique Michelle Date: 2022 Background Up to 59% of tuberculosis (TB)/human immunodeficiency virus (HIV) co-treated patients develop paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) after addition of antiretroviral (ARV) therapy to ... Read more
Exploring the effects of polymorphic variation on the stability and function of human cytochrome P450 enzymes in silico and in vitro

Author: Arendse, Lauren Beth Date: 2014 Cytochrome P450s are highly polymorphic enzymes responsible for the Phase I metabolism of over 80% of pharmaceutical drugs. Polymorphic variation can result in altered drug efficacy as well as adverse drug reactions so the lack of understanding ... Read more
Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms

Author: Nair, Omesan Date: 2014 Cytochrome P450 (CYPs) are a superfamily of heme containing enzymes that catalyse a diverse range of biological reactions. They are responsible for over 80% of primary metabolism of currently available drugs and are therefore central to its ... Read more
Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells

Author: Garnett, Shaun Date: 2019 Introduction Neurogenesis, the development of new neurons, starts soon after the formation of the neural tube and is largely completed by birth. Development of the brain after birth is mainly reliant on the formation of new connections between ... Read more
High throughput proteomic analysis of Mycobacterium tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS)

Author: Bell, Liam Templeton Date: 2012 Includes abstract. Includes bibliographical references. Read more
Integrative genomic analyses of bacterially-associated colorectal cancer

Author: Viljoen, Katie S Date: 2015 Sporadic colorectal cancer (CRC) has been linked to various lifestyle factors, including the consumption of alcohol and red meat, smoking, and obesity. CRC is one of most extensively characterised cancers, both at a molecular and 'omic' level; ... Read more
Isolation and characterisation of novel DNA aptamers against Mycobacterium tuberculosis biomarkers: new tools for tuberculosis diagnostics

Author: Amos-Brown, Bianca Date: 2018 Tuberculosis is a curable disease with an average treatment success rate of 86 %. Despite this, there were an estimated 1.5 million deaths due to tuberculosis in 2013, most of which occurred in low and middle income countries. In order to ... Read more
Modulation of protein expression in Mycobacterium tuberculosis-stimulated TB- IRIS patient-derived PBMCs by omega n-3 polyunsaturated fatty acids

Author: Barnabe, Marine Date: 2018 Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory disorder which affects up to 54% of TB-HIV co-infected patients. Its pathogenesis remains unclear, and although treatment with the corticosteroid ... Read more
P450 biochips : development of a protein microarray platform for investigating cytochrome P450 clinical drug metabolism

Author: Beeton-Kempen, Natasha Date: 2010 This thesis describes the development of a novel cytochrome P450 array format, the P450 Biochip that allows quantitative and truly high-throughput measurement of cytochrome P450-mediated turnover reactions in sub-nanolitre volumes. Read more
Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria

Author: Hobbs, Henriëtte Renée Date: 2015 We proposed that the development of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high ... Read more
Proteomic insights into the modulation of foetal neurogenesis by the anti-retroviral efavirenz

Author: Albeldas, Claudia Date: 2019 Background: South African guidelines recommend that HIV-positive pregnant women immediately initiate antiretroviral therapy (efavirenz, emtricitabine, and tenofovir), regardless of trimester. Efavirenz causes central nervous system neuropathy ... Read more
Proteomic investigation of blood-based biomarkers for the diagnosis of HIV-associated neurocognitive disorders

Author: Murugan, Brandon Dean Date: 2015 Background: South Africa has the fourth highest prevalence of Human Immunodeficiency Virus (HIV) in the world, with over 340 000 new infections in 2013 alone. Implementation of Highly Active Antiretroviral Treatment (HAART) regimens, has ... Read more

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