Browsing by Author "Birrer, Michael J"

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Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

Author: Chi, Ru-pin A ; van der Watt, Pauline ; Wei, Wei ; Birrer, Michael J ; Leaner, Virna D Date: 02 Feb 2021 Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin. ... Read more c b
p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts

Author: Holderness-Parker, Nina ; Donninger, Howard ; Birrer, Michael J ; Leaner, Virna D Date: 2013 Activating Protein 1 (AP-1) plays a vital role in cell proliferation, differentiation and apoptosis. While de-regulation of AP-1 has been linked to many cancers, little is known regarding its downstream transcriptional targets that associate ... Read more c b

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