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Browsing by Author "Barnes, Karen I"

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Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)

Author: Raman, Jaishree ; Kagoro, Frank M ; Mabuza, Aaron ; Malatje, Gillian ; Reid, Anthony ; Frean, John ; Barnes, Karen I Date: 22 Aug 2019 Abstract Background The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy ... Read more
Correction to: Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauf, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 19 Mar 2021 An amendment to this paper has been published and can be accessed via the original article. Read more c b
A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga

Author: Wilkins, Justin Date: 1999 Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district ... Read more
Development of harmonised approaches for detecting and recording participant-reported anti-malarial drug safety data: The Delphi process

Author: Mandimika, Nyaradzo Date: 2017 Eliciting adverse event (AE) and non-study medication reports from clinical research participants is integral for evaluating drug safety. However, using different methods to question participants yields inconsistent results, compromising the ... Read more
Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa

Author: Barnes, Karen I ; Durrheim, David N ; Little, Francesca ; Jackson, Amanda ; Mehta, Ushma ; Allen, Elizabeth ; Dlamini, Sicelo S ; Tsoka, Joyce ; Bredenkamp, Barry ; Mthembu, D Jotham Date: 2005 In KwaZulu-Natal strengthening of vector control and a change in antimalarial treatment policy to use of artemether-lumefantrine has been associated with a decrease in malaria cases, admissions, and deaths. Read more c b
Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa

Author: Barnes, Karen I ; Durrheim, David N ; Little, Francesca ; Jackson, Amanda ; Mehta, Ushma ; Allen, Elizabeth ; Dlamini, Sicelo S ; Tsoka, Joyce ; Bredekamp, Barry ; Mthembu, D Jotham ; White, Nicholas J ; Sharp, Brian L Date: 2005 Between 1995 and 2000, KwaZulu–Natal province, South Africa, experienced a marked increase in Plasmodium falciparum malaria, fuelled by pyrethroid and sulfadoxine-pyrimethamine resistance. In response, vector control was strengthened and ... Read more
Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger

Author: Denoeud-Ndam, Lise ; Dicko, Alassane ; Baudin, Elisabeth ; Guindo, Ousmane ; Grandesso, Francesco ; Diawara, Halimatou ; Sissoko, Sibiri ; Sanogo, Koualy ; Traoré, Seydou ; Keita, Sekouba ; Barry, Amadou ; de Smet, Martin ; Lasry, Estrella ; Smit, Michiel ; Wiesner, Lubbe ; Barnes, Karen I ; Djimde, Abdoulaye A ; Guerin, Philippe J ; Grais, Rebecca F ; Doumbo, Ogobara K ; Etard, Jean-François Date: 24 Oct 2016 Background: Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial ... Read more c b
Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial

Author: Allen, Elizabeth N ; Little, Francesca ; Camba, Tunisio ; Cassam, Yasmin ; Raman, Jaishree ; Boulle, Andrew ; Barnes, Karen I Date: 2009 BACKGROUND: An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique. METHODS: Between 2003 and 2005, ... Read more c b
Exploring the seasonality of reported treated malaria cases in Mpumalanga, South Africa

Author: Silal, Sheetal Prakash ; Barnes, Karen I ; Kok, Gerdalize ; Mabuza, Aaron ; Little, Francesca Date: 2013 South Africa, having met the World Health Organisation's pre-elimination criteria, has set a goal to achieve malaria elimination by 2018. Mpumalanga, one of three provinces where malaria transmission still occurs, has a malaria season subject ... Read more c b
Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out

Author: Raman, Jaishree ; Mauff, Katya ; Muianga, Pedro ; Mussa, Abdul ; Maharaj, Rajendra ; Barnes, Karen I Date: 2011 Antimalarial drug resistance is a major obstacle to malaria control and eventual elimination. The routine surveillance for molecular marker of resistance is an efficient way to assess drug efficacy, which remains feasible in areas where malaria ... Read more c b
Making data map-worthy—enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study

Author: Kagoro, Frank M. ; Allen, Elizabeth ; Mabuza, Aaron ; Workman, Lesley ; Magagula, Ray ; Kok, Gerdalize ; Davies, Craig ; Malatje, Gillian ; Guérin, Philippe J ; Dhorda, Mehul ; Maude, Richard J ; Raman, Jaishree ; Barnes, Karen I Date: 29 Jun 2022 Background Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected. ... Read more
Measuring resistance to malaria

Author: Barnes, Karen I ; Folb, Peter I Date: 2004 The paper by Randrianarivelojosia and colleagues in this issue of the Journal (p. 47) describes the in vitro susceptibility of Plasmodium falciparum in Madagascar and the Comoros Union to three of the commonly used antimalarial drugs in the ... Read more
Optimising methodology for the elicitation of participant-reported data relating to drug safety in resource poor settings

Author: Allen, Elizabeth Date: 2015 In addition to treating symptomatic patients, malaria prevention and elimination requires giving antimalarial drugs to asymptomatic or uninfected individuals. This shifts the harm-benefit balance and heightens the importance of accurately ... Read more
The pharmacodynamics and pharmacokenetics of rectal administration of artesunate in the initial treatment of moderately severe and severe malaria in South African adults in northern Kwazulu Natal

Author: Barnes, Karen I Date: 2004 Includes bibliographical references. Read more
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria

Author: Anyorigiya, Thomas Atingane Date: 2017 RATIONALE: The accurate measurement of antimalarial drug concentrations in key target patient groups is essential to ensure optimal dosing for malaria treatment and to distinguish between inadequate drug exposure and antimalarial resistance. ... Read more
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauff, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 06 Jan 2021 Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal ... Read more c b
Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

Author: Simpson, Julie A ; Agbenyega, Tsiri ; Barnes, Karen I ; Perri, Gianni Di ; Folb, Peter ; Gomes, Melba ; Krishna, Sanjeev ; Krudsood, Srivicha ; Looareesuwan, Sornchai ; Mansor, Sharif Date: 2006 A study of the population pharmacokinetics of intra-rectal artesunate in patients with moderately severe falciparum malaria found the pharmacokinetic properties of dihydroartemisinin were affected only by gender and body weight. Read more c b
Preventing antimalarial resistance with artemisinin-based combination therapy

Author: Barnes, Karen I Date: 2004 Malaria morbidity and mortality is rising, principally as a result of increasing antimalarial resistance. Resistance means that there is a shift to the right in the dose-response (concentration effect) relationship. Plasmodium falciparum has ... Read more
Preventing antimalarial resistance with artemisinin-based combination therapy

Author: Barnes, Karen I Date: 2004 Malaria morbidity and mortality is rising, principally as a result of increasing antimalarial resistance. Resistance means that there is a shift to the right in the dose-response (concentration effect) relationship. Plasmodium falciparum has ... Read more
The rationale and plan for creating a World Antimalarial Resistance Network (WARN)

Author: Sibley, Carol Hopkins ; Barnes, Karen I ; Plowe, Christopher V Date: 2007 Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout of effective new ... Read more c b

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