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Browsing by Author "Barnes, Karen"

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Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali

Author: Tekete, Mamadou ; Toure, Sekou ; Fredericks, Alfia ; Beavogui, Abdoul ; Sangare, Cheick ; Evans, Alicia ; Smith, Peter ; Maiga, Hamma ; Traore, Zoumana ; Doumbo, Ogobara ; Barnes, Karen ; Djimde, Abdoulaye Date: 2011 BACKGROUND:Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment. Yet, limited data is available on ... Read more c b
Eliciting harms data from trial participants: how perceptions of illness and treatment mediate recognition of relevant information to report

Author: Allen, Elizabeth ; Barnes, Karen ; Mushi, Adiel ; Massawe, Isolide ; Staedke, Sarah ; Mehta, Ushma ; Vestergaard, Lasse ; Lemnge, Martha ; Chandler, Clare Date: 2011 Background: There is no consensus on the ideal methodology for eliciting participant-reported harms, but question methods influence the extent and nature of data detected. This gives potential for measurement error and undermines meta-analyses ... Read more c b
Evaluating harm associated with anti-malarial drugs: a survey of methods used by clinical researchers to elicit, assess and record participant-reported adverse events and related data

Author: Allen, Elizabeth ; Chandler, Clare ; Mandimika, Nyaradzo ; Pace, Cheryl ; Mehta, Ushma ; Barnes, Karen Date: 2013 BACKGROUND:Participant reports of medical histories, adverse events (AE) and non-study drugs are integral to evaluating harm in clinical research. However, interpreting or synthesizing results is complicated if studies use different methods ... Read more c b
Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa

Author: Zikusooka, Charlotte Muheki Date: 2006 This study seeks to use the techniques of cost-effectiveness analysis to evaluate, within the context of effective vector control, the change to artemisinin-based combination therapies (ACTs) as first line malaria treatment and to evaluate ... Read more
How experiences become data: the process of eliciting adverse event, medical history and concomitant medication reports in antimalarial and antiretroviral interaction trials

Author: Allen, Elizabeth ; Mushi, Adiel ; Massawe, Isolide ; Vestergaard, Lasse ; Lemnge, Martha ; Staedke, Sarah ; Mehta, Ushma ; Barnes, Karen ; Chandler, Clare Date: 2013 BACKGROUND:Accurately characterizing a drug's safety profile is essential. Trial harm and tolerability assessments rely, in part, on participants' reports of medical histories, adverse events (AEs), and concomitant medications. Optimal methods ... Read more c b
Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia

Author: Barnes, Karen ; Chanda, Pascalina ; Ab Barnabas, Gebre Date: 2009 Malaria is one of the most significant causes of morbidity and mortality worldwide. Every year, nearly one million deaths result from malaria infection. Malaria can be controlled in endemic countries by using artemisinin-based combination ... Read more c b
Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN)

Author: Lourens, Chris ; Watkins, William ; Barnes, Karen ; Sibley, Carol ; Guerin, Philippe ; White, Nicholas ; Lindegardh, Niklas Date: 2010 BACKGROUND: The Worldwide Antimalarial Resistance Network (WWARN) is a global collaboration to support the objective that anyone affected by malaria receives effective and safe drug treatment. The Pharmacology module aims to inform optimal ... Read more c b
Joint models for nonlinear longitudinal profiles in the presence of informative censoring

Author: Chatora, Tinashe Date: 2018 Malaria is the parasitic disease which affects the most humans, with Plasmodium falciparum malaria being responsible for the majority of severe malaria and malaria related deaths. The asexual form of the parasite causes the signs and symptoms ... Read more
A mathematical modelling approach for the elimination of malaria in Mpumalanga, South Africa

Author: Silal, Sheetal Prakash Date: 2014 Mpumalanga in South Africa is committed to eliminating malaria by 2018 and efforts are increasing beyond that necessary for malaria control. The eastern border of Mpumalanga is most affected by malaria with imported cases in Mpumalanga ... Read more
A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

Author: Denoeud-Ndam, Lise ; Dicko, Alassane ; Baudin, Elisabeth ; Guindo, Ousmane ; Grandesso, Francesco ; Sagara, Issaka ; Lasry, Estrella ; Palma, Pedro ; Parra, Angeles ; Stepniewska, Kasia ; Djimde, Abdoulaye ; Barnes, Karen ; Doumbo, Ogobara ; Etard, Jean-Francois Date: 2015 BACKGROUND:Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severely malnourished children are systematically ... Read more c b
Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves

Author: Mauff, Katya Date: 2011 This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial ... Read more
Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

Author: Distiller, G B Date: 2007 Includes bibliographical references (leaves 96-102) Read more
Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

Author: Distiller, Greg ; Little, Francesca ; Barnes, Karen Date: 2010 BACKGROUND:Gametocytes are the sexual form of the malaria parasite and the main agents of transmission. While there are several factors that influence host infectivity, the density of gametocytes appears to be the best single measure that is ... Read more c b
Predicting the impact of border control on malaria transmission: a simulated focal screen and treat campaign

Author: Silal, Sheetal ; Little, Francesca ; Barnes, Karen ; White, Lisa Date: 2015 BACKGROUND: South Africa is one of many countries committed to malaria elimination with a target of 2018 and all malaria-endemic provinces, including Mpumalanga, are increasing efforts towards this ambitious goal. The reduction of imported ... Read more c b
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Author: Lee, Sue ; Stepniewska, Kasia ; Anstey, Nicholas ; Ashley, Elizabeth ; Barnes, Karen ; Binh, Tran ; D'Alessandro, Umberto ; Day, Nicholas ; de Vries, Peter ; Dorsey, Grant ; Guthmann, Jean-Paul ; Mayxay, Mayfong ; Newton, Paul ; Nosten, Francois ; Olliaro, Piero Date: 2008 BACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one ... Read more c b
Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?

Author: Zikusooka, Charlotte ; McIntyre, Diane ; Barnes, Karen Date: 2008 BACKGROUND: Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates ... Read more c b
Therapeutic efficacy of sulfadoxine-pyrimethamine for plasmodium falciparum malaria

Author: Mabuza, Aaron ; Govere, John ; La Grange, Kobus ; Mngomezulu, Nicros ; Allen, Elizabeth ; Zitha, Alpheus ; Mbokazi, Frans ; Durrheim, David ; Barnes, Karen Date: 2005 Objectives. To assess the therapeutic efficacy of sulfadoxinepyrimethamine (SP) after 5 years of use as first-line treatment of uncomplicated Plasmodium falciparum malaria, and thus guide the selection of artemisinin-based combination therapy ... Read more
Treating AIDS-associated cerebral toxoplasmosis - pyrimethamine plus sulfadiazine compared with cotrimoxazole, and outcome with adjunctive glucocorticoids

Author: Arens, James ; Barnes, Karen ; Crowley, Nicola ; Maartens, Gary Date: 2007 We conducted a retrospective study of AIDS-associated cerebral toxoplasmosis. Eighteen patients received pyrimethamine plus sulfadiazine and 25 co-trimoxazole, with comparable baseline characteristics. There were no differences in clinical ... Read more
World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology

Author: Barnes, Karen ; Lindegardh, Niklas ; Ogundahunsi, Olumide ; Olliaro, Piero ; Plowe, Christopher ; Randrianarivelojosia, Milijaona ; Gbotosho, Grace ; Watkins, William ; Sibley, Carol ; White, Nicholas Date: 2007 A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need changing. This ... Read more c b
World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs

Author: Price, Ric ; Dorsey, Grant ; Ashley, Elizabeth ; Barnes, Karen ; Baird, J Kevin ; d'Alessandro, Umberto ; Guerin, Philippe ; Laufer, Miriam ; Naidoo, Inbarani ; Nosten, Francois ; Olliaro, Piero ; Plowe, Christopher ; Ringwald, Pascal ; Sibley, Carol ; Stepniewska Date: 2007 The proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods ... Read more c b

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