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Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

Author: Rao, Vasudev ; Neogi, Ujjwal ; Talboom, Joshua ; Padilla, Ligia ; Rahman, Mustafizur ; Fritz-French, Cari ; Gonzalez-Ramirez, Sandra ; Verma, Anjali ; Wood, Charles ; Ruprecht, Ruth ; Ranga, Udaykumar ; Azim, Tasnim ; Joska, John ; Eugenin, Eliseo ; Shet, Anita ; B Date: 2013 BACKGROUND: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated dementia (HAD) in approximately 15% to 30% of the ... Read more c b

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