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Browsing by Author "Avenant, Chanel"

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Cross talk between the glucocorticoid receptor and the progesterone receptor in modulation of progestin responses and HIV-1 infection

Author: Bick, Alexis J Date: 2018 Current epidemiological data showing that the use of the injectable contraceptive progestin Depotmedroxyprogesterone acetate (DMPA) is associated with increased HIV-1 acquisition is controversial. However, animal and ex vivo data reveal ... Read more
Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants

Author: Ray, Roslyn Michelle Date: 2015 The synthetic progestogens, medroxyprogesterone acetate (MPA) and norethisterone enanthate (NET-EN),are widely used in developing countries as injectable contraceptives, where disease burden is high.Levonorgestrel (LNG) is a common progestogen ... Read more
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor

Author: Govender, Yashini ; Avenant, Chanel ; Verhoog, Nicolette J D ; Ray, Roslyn M ; Grantham, Nicholas J ; Africander, Donita ; Hapgood, Janet P Date: 2014 Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the injectable contraceptive norethisterone enanthate (NET-EN). We investigated the ... Read more c b
Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy

Author: Nhundu, Tawanda Date: 2018 Glucocorticoids (GCs) are steroid hormones widely prescribed to treat inflammatory disorders and are regarded as anti-inflammatory molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory ... Read more
Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins

Author: Grantham, N J Date: 2012 It has been 30 years since HIV was first discovered, yet the molecular mechanisms whereby the virus mediates its pathogenic effects have not yet been completely elucidated. The glucocorticoid receptor (GR) is a ligand-activated host transcription ... Read more
Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor

Author: Enfield, Kim Date: 2021 Hormonal contraceptives (HCs) and hormonal replacement therapies (HRTs) are widely used globally by women. However, the relative activity of some of the progestogens used in HCs and HRT has not been determined via their target steroid receptor ... Read more
Molecular mechanism of action of the glucocorticoid receptor:Role of ligand-dependent receptor phosphorylation and half-life in determination of ligand-specific transcriptional activity. : Contents Pages

Author: Avenant, Chanel Date: 2009 Glucocorticoids mediate their effects by binding to the glucocorticoid receptor (GR), resulting in modulation of transcription of target genes via direct binding to DNA or tethering via proteinprotein interactions. A central question is what ... Read more
The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+ T cells through the glucocorticoid receptor

Author: Tomasicchio, Michele ; Avenant, Chanel ; Toit, Andrea Du ; Ray, Roslyn M ; Hapgood, Janet P Date: 2013 The glucocorticoid receptor (GR) regulates several physiological functions, including immune function and apoptosis. The HIV-1 virus accessory protein, viral protein R (Vpr), can modulate the transcriptional response of the GR. Glucocorticoids ... Read more c b
Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens

Author: Govender, Yashini Date: 2015 The relationship between progestin-only injectable contraception and risk of HIV-1 acquisition is controversial. Most clinical data suggests that the injectable contraceptive medroxyprogesterone acetate (MPA), unlike norethisterone enanthate ... Read more
Synergism between immune activators and progestogens: differential effects on gene expression and HIV-1 replication and the role of the glucocorticoid receptor

Author: Moliki, Johnson Mosoko Date: 2018 Globally, women account for more than half of the 36.9 million people living with HIV-1. In some regions particularly Sub-Saharan Africa, women of child-bearing age are at great risk of being infected with HIV-1 than men of the same age group. ... Read more

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