Browsing by Author "Anderson, Suzanne"

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Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups

Author: Dissanayeke, Shobana Rebecca ; Levin, Samuel ; Pienaar, Sandra ; Wood, Kathryn ; Eley, Brian ; Beatty, David ; Henderson, Howard ; Anderson, Suzanne ; Levin, Michael Date: 2009 Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene ( TIRAP ) have been associated ... Read more c b
Tuberculosis and genes of the IL12/IL23/IFNγ pathway: Exploring functional significance of novel mutations in the IL12p40 promoter

Author: Pienaar, Sandra Margaret Date: 2014 The aim of this work was to screen the IL12p40 gene promoter for association with TB disease. Initially a subcohort of children (TB cases and healthy controls) from a TB-endemic area was screened for DNA changes by the WAVE method. Thereafter, ... Read more

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