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Browsing by Author "Allen, Elizabeth"

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A mixed method study of the factors influencing the validity of medical and medication histories obtained from potential healthy adult clinical trial participants

Author: Ltayef, Hanan Date: 2019 Background: The medical histories of patients are data picked up by a doctor by making inquiries of the patient and of other individuals who know the individual and can give a reasonable response. In clinical trials, obtaining an accurate ... Read more
Comparison of three levels of ascertainment of antenatal medication use at Gugulethu Midwife Obstetric Unit

Author: van Der Hoven, Jani Date: 2022 Background The use of medicines and/or remedies among pregnant women is common. Pregnant women are generally excluded from clinical trials due to ethical reasons. There are therefore minimal data available about the safety of most drugs during ... Read more
Development of harmonised approaches for detecting and recording participant-reported anti-malarial drug safety data: The Delphi process

Author: Mandimika, Nyaradzo Date: 2017 Eliciting adverse event (AE) and non-study medication reports from clinical research participants is integral for evaluating drug safety. However, using different methods to question participants yields inconsistent results, compromising the ... Read more
Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa

Author: Barnes, Karen I ; Durrheim, David N ; Little, Francesca ; Jackson, Amanda ; Mehta, Ushma ; Allen, Elizabeth ; Dlamini, Sicelo S ; Tsoka, Joyce ; Bredenkamp, Barry ; Mthembu, D Jotham Date: 2005 In KwaZulu-Natal strengthening of vector control and a change in antimalarial treatment policy to use of artemether-lumefantrine has been associated with a decrease in malaria cases, admissions, and deaths. Read more c b
Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa

Author: Barnes, Karen I ; Durrheim, David N ; Little, Francesca ; Jackson, Amanda ; Mehta, Ushma ; Allen, Elizabeth ; Dlamini, Sicelo S ; Tsoka, Joyce ; Bredekamp, Barry ; Mthembu, D Jotham ; White, Nicholas J ; Sharp, Brian L Date: 2005 Between 1995 and 2000, KwaZulu–Natal province, South Africa, experienced a marked increase in Plasmodium falciparum malaria, fuelled by pyrethroid and sulfadoxine-pyrimethamine resistance. In response, vector control was strengthened and ... Read more
Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial

Author: Allen, Elizabeth Date: 2008 [Background and rationale] Malaria accounts for a large public health burden in Mozambique and a treatment policy with effective anti-malarials is a key component of their malaria control programme. Artemisinin-based combination therapies ... Read more
Eliciting harms data from trial participants: how perceptions of illness and treatment mediate recognition of relevant information to report

Author: Allen, Elizabeth ; Barnes, Karen ; Mushi, Adiel ; Massawe, Isolide ; Staedke, Sarah ; Mehta, Ushma ; Vestergaard, Lasse ; Lemnge, Martha ; Chandler, Clare Date: 2011 Background: There is no consensus on the ideal methodology for eliciting participant-reported harms, but question methods influence the extent and nature of data detected. This gives potential for measurement error and undermines meta-analyses ... Read more c b
Evaluating harm associated with anti-malarial drugs: a survey of methods used by clinical researchers to elicit, assess and record participant-reported adverse events and related data

Author: Allen, Elizabeth ; Chandler, Clare ; Mandimika, Nyaradzo ; Pace, Cheryl ; Mehta, Ushma ; Barnes, Karen Date: 2013 BACKGROUND:Participant reports of medical histories, adverse events (AE) and non-study drugs are integral to evaluating harm in clinical research. However, interpreting or synthesizing results is complicated if studies use different methods ... Read more c b
How experiences become data: the process of eliciting adverse event, medical history and concomitant medication reports in antimalarial and antiretroviral interaction trials

Author: Allen, Elizabeth ; Mushi, Adiel ; Massawe, Isolide ; Vestergaard, Lasse ; Lemnge, Martha ; Staedke, Sarah ; Mehta, Ushma ; Barnes, Karen ; Chandler, Clare Date: 2013 BACKGROUND:Accurately characterizing a drug's safety profile is essential. Trial harm and tolerability assessments rely, in part, on participants' reports of medical histories, adverse events (AEs), and concomitant medications. Optimal methods ... Read more c b
Optimising methodology for the elicitation of participant-reported data relating to drug safety in resource poor settings

Author: Allen, Elizabeth Date: 2015 In addition to treating symptomatic patients, malaria prevention and elimination requires giving antimalarial drugs to asymptomatic or uninfected individuals. This shifts the harm-benefit balance and heightens the importance of accurately ... Read more
Protocol for a drugs exposure pregnancy registry for implementation in resource-limited settings

Author: Mehta, Ushma ; Clerk, Christine ; Allen, Elizabeth ; Yore, Mackensie ; Sevene, Esperanca ; Singlovic, Jan ; Petzold, Max ; Mangiaterra, Viviana ; Elefant, Elizabeth ; Sullivan, Frank ; Holmes, Lewis ; Gomes, Melba Date: 2012 BACKGROUND: The absence of robust evidence of safety of medicines in pregnancy, particularly those for major diseases provided by public health programmes in developing countries, has resulted in cautious recommendations on their use. We ... Read more c b
Quality assurance of qualitative research: a review of the discourse

Author: Reynolds, Joanna ; Kizito, James ; Ezumah, Nkoli ; Mangesho, Peter ; Allen, Elizabeth ; Chandler, Clare Date: 2011 BACKGROUND:Increasing demand for qualitative research within global health has emerged alongside increasing demand for demonstration of quality of research, in line with the evidence-based model of medicine. In quantitative health sciences ... Read more c b
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Author: Raman, Jaishree ; Allen, Elizabeth ; Workman, Lesley ; Mabuza, Aaron ; Swanepoel, Hendrik ; Malatje, Gillian ; Frean, John ; Wiesner, Lubbe ; Barnes, Karen I Date: 24 Jun 2019 Abstract Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment ... Read more
Therapeutic efficacy of sulfadoxine-pyrimethamine for plasmodium falciparum malaria

Author: Mabuza, Aaron ; Govere, John ; La Grange, Kobus ; Mngomezulu, Nicros ; Allen, Elizabeth ; Zitha, Alpheus ; Mbokazi, Frans ; Durrheim, David ; Barnes, Karen Date: 2005 Objectives. To assess the therapeutic efficacy of sulfadoxinepyrimethamine (SP) after 5 years of use as first-line treatment of uncomplicated Plasmodium falciparum malaria, and thus guide the selection of artemisinin-based combination therapy ... Read more

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Browsing by Author "Allen, Elizabeth"

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