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Browsing by Author "Williamson, Anna-Lise"

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Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus

Author: Suzuki, Akiko Date: 2019 Bovine leukaemia virus (BLV) and lumpy skin disease virus (LSDV) are endemic to Africa and cause significant economic losses to the beef and dairy industries. Vaccines are the most cost-effective and efficient way to prevent infection and ... Read more
The Development of Dual Vaccines against Lumpy Skin Disease (LSD) and Bovine Ephemeral Fever (BEF)

Author: Douglass, Nicola ; Omar, Ruzaiq ; Munyanduki, Henry ; Suzuki, Akiko ; de Moor, Warren ; Mutowembwa, Paidamwoyo ; Pretorius, Alri ; Nefefe, Tshifhiwa ; Schalkwyk, Antoinette van ; Kara, Pravesh ; Heath, Livio ; Williamson, Anna-Lise Date: 20 Oct 2021 Dual vaccines (<i>n</i> = 6) against both lumpy skin disease (LSD) and bovine ephemeral fever (BEF) were constructed, based on the BEFV glycoprotein (G) gene, with or without the BEFV matrix (M) protein gene, inserted into one of two different ... Read more c b
The development of novel HIV-1 vaccines using modified recombinant BCG

Author: Chetty, Shivan Date: 2016 Vaccination continues to represent the most effective means of providing immunological protection against infectious disease in human populations. With the World Health Organisation (WHO) reporting over 1.2 million AIDS related deaths in 2014, ... Read more
The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1

Author: Hu, Nai-Chung Date: 2010 Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus recombinant to protect humans against HIV-1 ... Read more
The development of recombinant lumpy skin disease virus vaccines for foot-and-mouth disease and rift valley fever

Author: Johnston, Nicolette Michelle Edith Date: 2001 Bibliography: leaves 142-158. Read more
Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa

Author: Taku, Ongeziwe ; Mbulawa, Zizipho Z A ; Phohlo, Keletso ; Garcia-Jardon, Mirta ; Businge, Charles B ; Williamson, Anna-Lise Date: 11 Feb 2021 South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical ... Read more c b
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity

Author: Mbele, Prisca Date: 2011 The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. Read more
Evolutionary dynamics of ten novel Gamma-PVs: insights from phylogenetic incongruence, recombination and phylodynamic analyses

Author: Murahwa, Alltalents T ; Nindo, Fredrick ; Onywera, Harris ; Meiring, Tracy L ; Martin, Darren P ; Williamson, Anna-Lise Date: 14 May 2019 Abstract Background Human papillomaviruses (HPVs) are genetically diverse, belonging to five distinct genera: Alpha, Beta, Gamma, Mu and Nu. All papillomaviruses have double stranded DNA genomes ... Read more
Expression of HIV-1 antigens in plants as potential subunit vaccines

Author: Meyers, Ann ; Chakauya, Ereck ; Shephard, Enid ; Tanzer, Fiona ; Maclean, James ; Lynch, Alisson ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2008 BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) has infected more than 40 million people worldwide, mainly in sub-Saharan Africa. The high prevalence of HIV-1 subtype C in southern Africa necessitates the development of cheap, effective ... Read more c b
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

Author: Chatterjee, Koushik ; Engelmark, Malin ; Gyllensten, Ulf ; Dandara, Collet ; Merwe, Lize ; Galal, Ushma ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2009 BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated ... Read more c b
Generation and characterization of HIV-1 subtype C candidate vaccines that will induce high titre antibody responses to HIV-1 envelope glycoprotein

Author: van Diepen, Michiel Theodoor Date: 2020 Despite huge strides being made towards decreasing the number of individuals getting newly infected with HIV-1, and in reducing AIDS-related deaths, unfortunately current predictions are that the 2020 UNAIDS goals (90-90-90 targets, where 90% ... Read more
Genetic and phenotypic analysis of novel South African Avian poxviruses

Author: Carulei, Olivia Date: 2018 Avian poxviruses are important pathogens of both wild and domestic birds and exhibit a large degree of intragenus diversity at a genomic level. These viruses are known to differ in growth characteristics (in vitro and in vivo), virulence, and ... Read more
Genetic characterisation of six novel African swine fever viruses isolated from a pig, warthog, wild boar, and ticks

Author: Ndlovu, Sandy Sibusiso Date: 2021 African swine fever (ASF) is a disease that affects domestic pigs and wild boars, resulting in up to 100% case fatality rate, and there is currently no effective treatment or vaccine. To date, there are 67 ASFV complete genome sequences ... Read more
High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa

Author: Ebrahim, Sumayyah ; Mndende, Xolani K ; Kharsany, Ayesha B M ; Mbulawa, Zizipho Z A ; Naranbhai, Vivek ; Frohlich, Janet ; Werner, Lise ; Samsunder, Natasha ; Karim, Quarraisha Abdool ; Williamson, Anna-Lise Date: 2016 Objectives HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 ... Read more c b
HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study

Author: Moodley, Jennifer ; Hoffman, Margaret ; Carrara, Henri ; Allan, Bruce ; Cooper, Diane ; Rosenberg, Lynn ; Denny, Lynette ; Shapiro, Samuel ; Williamson, Anna-Lise Date: 2006 BACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both major public health problems in South Africa. The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women ... Read more c b
HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice

Author: Pillay, Sirika ; Shephard, Enid ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2010 Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag protein is an excellent vaccine ... Read more c b
HIV-1 subtype C mosaic Gag expressed by BCG and MVA elicits persistent effector t cell responses in a prime-boost regimen in mice

Author: Jongwe, Tsungai Ivai ; Chapman, Ros ; Douglass, Nicola ; Chetty, Shivan ; Chege, Gerald ; Williamson, Anna-Lise Date: 2016 Over 90% of HIV/AIDS positive individuals in sub-Saharan Africa are infected with highly heterogeneous HIV-1 subtype C (HIV-1C) viruses. One of the best ways to reduce the burden of this disease is the development of an affordable and effective ... Read more c b
Human Immunodeficiency Virus/Human Papillomavirus co-infection and host molecular genetics of cervical carcinoma

Author: Chambuso, Ramadhani Salum Date: 2019 A subgroup of women who are co-infected with human immunodeficiency virus type 1 (HIV1) and human papillomavirus (HPV) progress relatively rapidly to cervical disease regardless of the number of absolute CD4 count. During infection, viral ... Read more
Human papillomavirus prevalence in South African women and men according to age and human immunodeficiency virus status

Author: Mbulawa, Zizipho Z A ; Coetzee, David ; Williamson, Anna-Lise Date: 26 Oct 2015 Background: Both cervical cancer and human immunodeficiency virus (HIV) are major public health problems in Sub-Saharan Africa. The objectives of the study were to investigate human papillomavirus (HPV) prevalence according to age, HIV status ... Read more
Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Author: Maueia, Cremildo ; Murahwa, Alltalents ; Manjate, Alice ; Andersson, Soren ; Sacarlal, Jahit ; Kenga, Darlene ; Mussá, Tufária ; Williamson, Anna-Lise Date: 23 Dec 2021 Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are ... Read more c b

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