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Browsing by Author "Wiesner, Lubbe"

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Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

Author: Lombard, Marli ; N'Da, David ; Tran Van Ba, Christophe ; Wein, Sharon ; Norman, Jennifer ; Wiesner, Lubbe ; Vial, Henri Date: 2013 BACKGROUND:Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized artemisinin-aminoquinoline ... Read more c b
Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads

Author: Strydom, Natasha Date: 2018 Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential ... Read more
Progress towards the UNAIDS 90–90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa: a household-based community cross-sectional survey

Author: Huerga, Helena ; Van Cutsem, Gilles ; Ben Farhat, Jihane ; Puren, Adrian ; Bouhenia, Malika ; Wiesner, Lubbe ; Dlamini, Linda ; Maman, David ; Ellman, Tom ; Etard, Jean-François Date: 02 Mar 2018 Abstract Background The Joint United Nations Programme on HIV/AIDS (UNAIDS) has developed an ambitious strategy to end the AIDS epidemic. After eight years of antiretroviral therapy (ART) ... Read more
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Author: Raman, Jaishree ; Allen, Elizabeth ; Workman, Lesley ; Mabuza, Aaron ; Swanepoel, Hendrik ; Malatje, Gillian ; Frean, John ; Wiesner, Lubbe ; Barnes, Karen I Date: 24 Jun 2019 Abstract Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment ... Read more
Screening of actinobacteria for novel antimalarial compounds

Author: Watson, Daniel John Date: 2020 The success of our first-line antimalarial treatments is threatened by increased drug resistance in Plasmodium parasites. This makes the development of novel drugs critical to combat malaria. Historically, natural products have been an excellent ... Read more
Screening rare filamentous actinobacteria for novel antimycobacterial compounds

Author: Soshankana, Lithakazi Date: 2021 Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M.tb). According to the World Health Organization (WHO), TB is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious ... Read more
Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma

Author: Mazanhanga, Marian Tafadzwa Date: 2019 Tuberculosis (TB) currently kills more people than any other infectious disease worldwide, the highest burden being in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), ... Read more
The Development and Validation of a Direct LC-MS/MS Assay for the Determination of Tenofovir-diphosphate in Dried Blood Spots for the Analysis of Clinical Samples

Author: Oberholster, Lucas Date: 2019 Tenofovir (TFV) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors, often used in preexposure prophylaxis (PrEP) trials: where antiretroviral drugs are administered to high-risk, HIV-negative individuals to prevent HIV ... Read more

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