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Browsing by Author "Mayosi, Bongani M"

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Genetic susceptibility to acute rheumatic fever: a systematic review and meta-analysis of twin studies

Author: Engel, Mark E ; Stander, Raphaella ; Vogel, Jonathan ; Adeyemo, Adebowale A ; Mayosi, Bongani M Date: 2011 BACKGROUND: Acute rheumatic fever is considered to be a heritable condition, but the magnitude of the genetic effect is unknown. The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance ... Read more c b
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa

Author: Okpechi, Ikechi G ; Rayner, Brian L ; van der Merwe, Lize ; Mayosi, Bongani M ; Adeyemo, Adebowale ; Tiffin, Nicki ; Ramesar, Rajkumar Date: 2010 BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. Obesity is a risk factor for CKD and ... Read more c b
Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness

Author: Rahman, Thahira J ; Walker, Elizabeth A ; Mayosi, Bongani M ; Hall, Darroch H ; Avery, Peter J ; Connell, John M C ; Watkins, Hugh ; Stewart, Paul M ; Keavney, Bernard Date: 2011 Objective The combined thickness of the intima and media of the carotid artery (carotid intima-medial thickness, CIMT) is associated with cardiovascular disease and stroke. Previous studies indicate that carotid intima-medial thickness is a ... Read more c b
HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study

Author: Ntsekhe, Mpiko ; Wiysonge, Charles S ; Gumedze, Freedom ; Maartens, Gary ; Commerford, Patrick J ; Volmink, Jimmy A ; Mayosi, Bongani M Date: 2008 BACKGROUND: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection ... Read more c b
HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-gp120 aptamer

Author: de Campos, Walter R Lopes ; Chirwa, Nthato ; London, Grace ; Rotherham, Lia S ; Morris, Lynn ; Mayosi, Bongani M ; Khati, Makobetsa Date: 2014 HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated ... Read more c b
Hydatid disease - the 'water lily' sign

Author: Smedema, Elmarie ; Mayosi, Bongani M ; Smedema, Jan-Peter Date: 2006 A 30-year-old black woman with hydatid liver disease and HIV infection (World Health Organization stage III) presented with symptoms of heart failure. Echocardiography showed global impairment of the left ventricular function (ejection fraction ... Read more
The initiative to investigate the management of Pericarditis in Africa (IMPI) Registry : a substudy on the causes of constrictive pericarditis and predictors of mortality in patients with constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital (The Constrictive Pericarditis Substudy)

Author: Mutyaba, Arthur Kaggwe Date: 2015 Background: Causes of constrictive pericarditis and predictors of peri-operative outcome following pericardiectomy are not clearly elucidated, especially in Africa, where disease characteristics differ from developed countries. Furthermore, ... Read more
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever - a systematic review

Author: Manyemba, Juliet ; Mayosi, Bongani M Date: 2003 Background. People with a history of rheumatic fever (RF) are at high risk of recurrent attacks and of developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent ... Read more
Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model

Author: Gumede, Dimakatso B Date: 2019 Hereditary fibrosing poikiloderma is an autosomal dominant disorder that is characterised by mottled pigmentation and telangiectasia, accompanied by tendon contractures, myopathy and pulmonary fibrosis (POIKTMP). Mutations in POIKTMP cases ... Read more
Lack of adherence to the national guidelines on the prevention of rheumatic fever

Author: Robertson, Katharine A ; Volmink, Jimmy A ; Mayosi, Bongani M Date: 2005 Objectives. To explore the extent to which current practices for the secondary prevention of rheumatic fever (RF) in Cape Town adhere to those outlined in the national guidelines on the primary prevention and prophylaxis of RF and rheumatic ... Read more
Molecular genetics of arrhythmogenic right ventricular and dilated cardiomyopathy in South Africans

Author: Mbele, Mzwandile Date: 2014 Introduction: Little is known about the molecular genetics of cardiomyopathy in Africans. Aims: to (I) determine the prevalence of desmosomal gene mutations in arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy ... Read more
Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.

Author: Mayosi, Bongani M ; Wiysonge, Charles Shey ; Ntsekhe, Mpiko ; Gumedze, Freedom ; Volmink Jimmy A ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby M ; Thomas, Kandathil M ; Awotedu, Abolade A ; Bongani, Thembela ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen Ngu ; Nkouonlack, Duquesne C ; Burch, Vanessa C ; Rebe, Kevin ; Parrish, Andy ; Sliwa, Karen ; Vezi, Brian Z ; Alam, Nowshad ; Brown, Basil G ; Gould, Trevor ; Visser, Tim ; Magula, Nombulelo P ; Commerford, Patrick J Date: 2008 Tuberculous pericarditis is one of the most severe forms of extrapulmonary tuberculosis, causing death or disability in a substantial proportion of affected people.1,2 In Africa, the incidence of tuberculous pericarditis is rising as a result ... Read more
Mycobacterium W immunotherapy for treating pulmonary tuberculosis : a systematic review

Author: Pandie, Shaheen Date: 2011 Tuberculosis (TB) remains a major health problem in the developing world, accounting for approximately 2 million deaths per year. The search for appropriate and applicable therapies to reduce the burden of TB is essential. Mycobacterium w (M ... Read more
Notification of rheumatic fever in South Africa - evidence for underreporting by health care professionals and administrators

Author: Nkgudi, Boitumelo ; Robertson, Kate A ; Volmink, Jimmy ; Mayosi, Bongani M Date: 2006 Objective. To determine whether under-reporting of rheumatic fever occurs at hospital, municipal, provincial and national levels of the South African health system. Background. Information on the incidence of rheumatic fever (RF) and the ... Read more
Outcomes of asymptomatic and symptomatic rheumatic heart disease

Author: Zühlke, Liesl Joanna Date: 2015 Rheumatic Heart Disease (RHD) is a leading cause of heart disease in children and young adults in the developing world, with significant associated morbidity and mortality. Early secondary prophylaxis may retard the deleterious progression ... Read more
Pentoxifylline for heart failure: A systematic review

Author: Batchelder, Kathryn ; Mayosi, Bongani M Date: 2005 Background. Recent trials have indicated a beneficial effect of pentoxifylline on measures of inflammation and markers of cardiac dysfunction in people with heart failure. However, it is uncertain whether pentoxifylline should be used routinely ... Read more
Performance of re-used pacemakers and implantable cardioverter defibrillators compared with new devices at Groote Schuur Hospital, Cape Town, South Africa

Author: Jama, Zimasa Vuyo Date: 2016 Objectives: Little is known about the performance of re - used pacemakers and implantable cardioverter defibrillators (ICDs) in Africa. We sought to compare the risk of infection and the rate of malfunction of re - used pacemakers and ICDs ... Read more
Pregnancy-associated heart failure: a comparison of clinical presentation and outcome between hypertensive heart failure of pregnancy and idiopathic peripartum cardiomyopathy

Author: Ntusi, Ntobeko B A ; Badri, Motasim ; Gumedze, Freedom ; Sliwa, Karen ; Mayosi, Bongani M Date: 2015 AIMS: There is controversy regarding the inclusion of patients with hypertension among cases of peripartum cardiomyopathy (PPCM), as the practice has contributed significantly to the discrepancy in reported characteristics of PPCM. We sought ... Read more c b
Preliminary genealogical evidence for the Plakophilin-2 gene, PKP2 c.1162C>T founder mutation in cases with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Author: Machipisa, Tafadzwa Date: 2016 Introduction: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive form of inherited heart muscle disease characterized by ventricular arrhythmias and sudden cardiac death. Often the pathogenesis is linked to deleterious ... Read more
Prevalence of rheumatic heart disease in Zambian school children

Author: Schwaninger, Sherri ; Musuku, John ; Engel, Mark E ; Musonda, Patrick ; Lungu, Joyce C ; Machila, Elizabeth ; Mtaja, Agnes ; Mulendele, Evans ; Kavindele, Dorothy ; Spector, Jonathan ; Tadmor, Brigitta ; Gutierrez, Marcelo M ; Van Dam, Joris ; Colin, Laurence ; Long, Aidan ; Fishman, Mark C ; Mayosi, Bongani M ; Zühlke, Liesl J Date: 03 Jul 2018 Background The large global burden of rheumatic heart disease (RHD) has come to light in recent years following robust epidemiologic studies. As an operational research component of a broad program aimed at primary and secondary ... Read more

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