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Browsing by Author "Little, Francesca"

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Impact of Xpert MTB/RIF for TB diagnosis in a primary care clinic with high TB and HIV prevalence in South Africa: a pragmatic randomised trial

Author: Cox, Helen S ; Mbhele, Slindile ; Mohess, Neisha ; Whitelaw, Andrew ; Muller, Odelia ; Zemanay, Widaad ; Little, Francesca ; Azevedo, Virginia ; Simpson, John ; Boehme, Catharina C ; Nicol, Mark P Date: 2014 Background: Xpert MTB/RIF is approved for use in tuberculosis (TB) and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpert under routine conditions in settings with high TB burden. Methods and Findings: A pragmatic ... Read more c b
Investigating the relationship between mobile network performance metrics and customer satisfaction

Author: Labuschagne, Louwrens Date: 2019 Fixed and mobile communication service providers (CSPs) are facing fierce competition among each other. In a globally saturated market, the primary di↵erentiator between CSPs has become customer satisfaction, typically measured by the Net ... Read more
Joint models for nonlinear longitudinal profiles in the presence of informative censoring

Author: Chatora, Tinashe Date: 2018 Malaria is the parasitic disease which affects the most humans, with Plasmodium falciparum malaria being responsible for the majority of severe malaria and malaria related deaths. The asexual form of the parasite causes the signs and symptoms ... Read more
Latent Variable Models for Longitudinal Outcomes from a Parenting Intervention Study

Author: Mccready, Carlyle Date: 2019 This research project analysed data collected with the use of self-reporting questionnaires and observational video scores in order to determine the level of success achieved by the Sinovuyo Caring Families Programme (SCFP). The SCFP aimed ... Read more
Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven

Author: Van Biljon, Noëlle Date: 2020 HIV infected (HIV+) children initiate antiretroviral therapy (ART) early in life and remain on it lifelong. However, the long-term impact of ART and HIV on the maturing brain is not well documented and longitudinal neuroimaging studies are ... Read more
A mathematical modelling approach for the elimination of malaria in Mpumalanga, South Africa

Author: Silal, Sheetal Prakash Date: 2014 Mpumalanga in South Africa is committed to eliminating malaria by 2018 and efforts are increasing beyond that necessary for malaria control. The eastern border of Mpumalanga is most affected by malaria with imported cases in Mpumalanga ... Read more
Modelling gametocytes in the presence of interval-censoring

Author: Takawira, Michaela Faro C Date: 2022 Malaria is a parasitic disease that has afflicted many over the years, with Plasmodium falciparum malaria accounting for many deaths. Gametocytes are the sexual form of the parasite responsible for transmitting and spreading malaria from the ... Read more
Modelling growth patterns of bird species using non-linear mixed effects models

Author: Ntirampeba, D Date: 2008 The analysis of growth data is important as it allows us to assess how fast things grow and determine various factors that have impact on their growth. In the current study, growth measurements on body features (body mass, wing length, head ... Read more
Modelling hepatotoxicity in HIV/TB co-infected patients: extensions of the Cox Proportional Hazards Model

Author: Mlotshwa, Vintia Philile Date: 2020 Hepatotoxicity which is also known as liver damage is mainly caused by intake of medicine. It is common among patients who are co-administering Tuberculosis (TB) treatment and the antiretroviral therapy (ART) for the Human Immunodeficiency ... Read more
Modelling Multivariate Nonlinear Vaccine Induced Immune Responses

Author: Lapham, Brendon M Date: 2020 Interpretable statistical models for multivariate vaccine induced immune response data are important as they provide a rigorous means of deciding which vaccine candidates should be advanced in the clinical trials process. We consider applications ... Read more
Multivariate analysis of the immune response upon recent acquisition of Mycobacterium tuberculosis infection

Author: Lloyd, Tessa Date: 2021 Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (M.tb), is the leading cause of mortality due to an infectious agent worldwide. Based on data from an adolescent cohort study carried out from May 2005 to February 2009, we ... Read more
Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves

Author: Mauff, Katya Date: 2011 This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial ... Read more
Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

Author: Distiller, G B Date: 2007 Includes bibliographical references (leaves 96-102) Read more
Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

Author: Distiller, Greg ; Little, Francesca ; Barnes, Karen Date: 2010 BACKGROUND:Gametocytes are the sexual form of the malaria parasite and the main agents of transmission. While there are several factors that influence host infectivity, the density of gametocytes appears to be the best single measure that is ... Read more c b
Performance analysis of text classification algorithms for PubMed articles

Author: Savvi, Suzana Date: 2021 The Medical Subject Headings (MeSH) thesaurus is a controlled vocabulary developed by the US National Library of Medicine (NLM) for indexing articles in Pubmed Central (PMC) archive. The annotation process is a complex and time-consuming task ... Read more
The pharmacodynamics and pharmacokenetics of rectal administration of artesunate in the initial treatment of moderately severe and severe malaria in South African adults in northern Kwazulu Natal

Author: Barnes, Karen I Date: 2004 Includes bibliographical references. Read more
Predicting the impact of border control on malaria transmission: a simulated focal screen and treat campaign

Author: Silal, Sheetal ; Little, Francesca ; Barnes, Karen ; White, Lisa Date: 2015 BACKGROUND: South Africa is one of many countries committed to malaria elimination with a target of 2018 and all malaria-endemic provinces, including Mpumalanga, are increasing efforts towards this ambitious goal. The reduction of imported ... Read more c b
Prevalence and incidence of renal dysfunction in patients initiating Antiretroviral Therapy at a Primary Health Care Centre in Gugulethu, Cape Town : a cohort study

Author: Kamkuemah, Monika Date: 2013 Tenofovir disoproxil fumarate (TDF) is used worldwide for the treatment of HIV-1 infection. Tenofovir has been found to be associated with declines in renal function and chronic kidney disease in HIV-infected patients. There are limited data ... Read more
A simulation model of antimalarial drug resistance

Author: Silal, Sheetal Prakash Date: 2009 Malaria ranks among the world's most important tropical parasitic diseases with world prevalence figures between 350 and 550 million clinical cases per annum. [WHO, 2008a] 'Treatment and prevention of malaria places a considerable burden on ... Read more
The smooth is better than the rough : an exploitation of reporting rate information in Southern Africa bird atlas data

Author: Little, Francesca Date: 2003 The Southern African Bird Atlas Project (Harrison at el. 1997a, b) and the Mozambique Bird Atlas Project (Parker 1999) generated data on reporting rates for birds that takes into account the likelihood of species detection in a given area. ... Read more

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