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Browsing by Author "Engel, Mark E"

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Long term outcome and the validity of EuroSCORE II in native-valve surgery for active endocarditis in a South African cohort

Author: Koshy, Jithan Jacob Date: 2015 Infective endocarditis was initially described in the early 16th century and only methodically reviewed after the 19th century when Osler gave the drive to the Royal College of Physicians in 1885 through his contribution. The last 25 years ... Read more
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study

Author: Shaboodien, Gasnat ; Engel, Mark E ; Syed, Faisal ; Poulton, Joanna ; Badri, Motasim ; Mayosi, Bongani Date: 2009 BACKGROUND: The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10-12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. We hypothesized ... Read more c b
Mobile phone text messaging for improving the uptake of vaccinations : a systematic review

Author: Kalan, Robyn Date: 2014 The research undertaken for this MPH dissertation examines the effectiveness of SMS as an intervention to promote vaccination. Part A is the research protocol, which outlines the background and the process of this research. This study ... Read more
Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis

Author: Barth, Dylan D ; Daw, Jessica ; Xu, Ruomei ; Enkel, Stephanie ; Pickering, Janessa ; McRae, Tracy ; Engel, Mark E ; Carapetis, Jonathan ; Wyber, Rosemary ; Bowen, Asha C Date: 31 Mar 2021 Background Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current ... Read more c b
N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol

Author: Chughlay, Mohamed ; Kramer, Nicole ; Werfalli, Mahmoud ; Spearman, Wendy ; Engel, Mark E ; Cohen, Karen Date: 2015 BACKGROUND: Drug-induced liver injury (DILI) refers to acute or chronic liver injury that may occur as a consequence of using drugs and herbal or dietary supplements. Specific therapies for DILI are limited. There is considerable evidence for ... Read more c b
Outcomes of asymptomatic and symptomatic rheumatic heart disease

Author: Zühlke, Liesl Joanna Date: 2015 Rheumatic Heart Disease (RHD) is a leading cause of heart disease in children and young adults in the developing world, with significant associated morbidity and mortality. Early secondary prophylaxis may retard the deleterious progression ... Read more
Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research

Author: Munro, Salla A ; Lewin, Simon A ; Smith, Helen J ; Engel, Mark E ; Fretheim, Atle ; Volmink, Jimmy Date: 2007 From a systematic review of qualitative research, Munro and coauthors found that a range of interacting factors can lead to patients deciding not to complete their course of tuberculosis treatment. Read more c b
The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review

Author: Moloi, Annesinah Date: 2015 Asymptomatic children can be a major reservoir of pharyngeal Group A Streptococcus (GAS) with reported figures ranging from <10% to >20% in developing countries. There is a need to document GAS carriage in school children, which, together ... Read more
Prevalence of Human papillomavirus among women following HPV vaccine introduction; a systematic review

Author: Muusha, Prudence Date: 2018 Background: Worldwide efforts have been made by some countries to offer HPV vaccination since its introduction in 2006. Population effectiveness of HPV vaccines is presently an active area of research. We review available evidence on the ... Read more
Prevalence of rheumatic heart disease in Zambian school children

Author: Schwaninger, Sherri ; Musuku, John ; Engel, Mark E ; Musonda, Patrick ; Lungu, Joyce C ; Machila, Elizabeth ; Mtaja, Agnes ; Mulendele, Evans ; Kavindele, Dorothy ; Spector, Jonathan ; Tadmor, Brigitta ; Gutierrez, Marcelo M ; Van Dam, Joris ; Colin, Laurence ; Long, Aidan ; Fishman, Mark C ; Mayosi, Bongani M ; Zühlke, Liesl J Date: 03 Jul 2018 Background The large global burden of rheumatic heart disease (RHD) has come to light in recent years following robust epidemiologic studies. As an operational research component of a broad program aimed at primary and secondary ... Read more
Rationale and design of the African group A streptococcal infection registry: the AFROStrep study

Author: Engel, Mark E ; Barth, Dylan D Date: 01 Feb 2016 Introduction: Group A β-haemolytic Streptococcus (GAS), a Gram-positive bacterium, also known as Streptococcus pyogenes, causes pyoderma, pharyngitis and invasive disease. Repeated GAS infections may lead to autoimmune diseases such as acute ... Read more c b
Reference intervals for the echocardiographic measurements of the right heart in African school children and adolescents

Author: Lemmer, Carolina Elisabet Date: 2011 Echocardiography is the primary imaging modality for the diagnosis and management of right ventricular (RV) failure.[2-5] Besides aiding in the diagnosis and management of conditions such as arrhythmogenic right ventricular cardiomyopathy, ... Read more
Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review

Author: Lemmer (Hunsinger), Carolina ; Engel, Mark E ; Stanfliet, John ; Mayosi, Bongani Date: 2014 BACKGROUND: Transthoracic echocardiography is the primary imaging modality for the diagnosis of right ventricular (RV) involvement in congenital and acquired heart diseases. There is increasing recognition of the contribution of RV dysfunction ... Read more c b
Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review

Author: Lemmer, Carolina Elisabet ; Engel, Mark E ; Stanfliet, John C ; Mayosi, Bongani M Date: 29 Jan 2014 Background: Transthoracic echocardiography is the primary imaging modality for the diagnosis of right ventricular (RV) involvement in congenital and acquired heart diseases. There is increasing recognition of the contribution of RV dysfunction ... Read more c b
Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: A systematic review

Author: Telford, Lisa Helen Date: 2018 Rheumatic heart disease (RHD) is a permanent heart valve condition resulting from an abnormal immune reaction to group A streptococcal (GAS) infection typically occurring in childhood. If left untreated, disease progression can result in ... Read more
Steroids for tuberculous pleurisy : a systematic review and meta-analysis of clinical trials

Author: Engel, Mark E Date: 2004 Corticosteroids used in addition to anti-tuberculous therapy have been reported to benefit people with tuberculous pleurisy. However, research findings are not consistent, raising doubt as to whether such treatment is worthwhile. Concem also ... Read more
Stigma and African genomics research: An exploration of stigma associated with the genetic attribution of rheumatic heart disease

Author: Faure, Marlyn Collin Date: 2018 There is mixed evidence about how genetic attribution of disease may impact on stigma. One theory, based on essentialism, argues that knowledge of genetic attribution may increase stigma, while attribution theory argues that bio-genetic ... Read more
A study of determinants and prevalence of Rheumatic Heart Disease in Cape Town

Author: Engel, Mark E Date: 2012 Rheumatic Heart Disease (RHD) is a post-infectious immune disease ascribed to an interaction between a rheumatogenic strain of group A streptococcus, a susceptible host who lives in poor social conditions with limited access to medical ... Read more
The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis

Author: Muloiwa, Rudzani ; Kagina, Benjamin M ; Engel, Mark E ; Hussey, Gregory D Date: 28 Aug 2020 Abstract Background An effective vaccine against Bordetella pertussis was introduced into the Expanded Programme on Immunisation (EPI) by WHO in 1974, leading to a substantial global reduction in pertussis morbidity and mortality. In low- ... Read more
The effectiveness of school-based interventions addressing adolescent mental health in Low- and Middle-Income Countries: A Systematic Review and Meta Analysis

Author: Albertus, Cleo Alyssa Date: 2020 Mental health is fundamental to a person's wellbeing and quality of life, as well as, influences social and economic outcomes across an individual's lifespan (Barry, Clarke, Jenkins, & Patel, 2013). The World Health Organization (WHO) ... Read more

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