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Browsing by Author "Dandara, Collet"

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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients

Author: Kampira, Elizabeth Date: 2013 Infectious diseases are endemic in Africa, especially tuberculosis (TB), malaria and human immunodefiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Genomics research has the potential to improve the health of Africans through ... Read more
Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs

Author: Mnika,Khuthala Date: 2020 Sickle cell disease (SCD) is a common blood disease caused by a single nucleotide substitution (c.20T>A, p.Glu6Val) in the beta globin gene on chromosome 11. The prevalence of the disease is high throughout large areas in sub-Saharan Africa, ... Read more
The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients

Author: Mpeta, Bafokeng Date: 2015 The Sub-Saharan African region remains the most severely affected by the HIV/AIDS epidemic. At the end of 2011, The Joint United Nations Programme on HIV/AIDS (UNAIDS) estimated that about 5% of adults were living with the HIV in this region, ... Read more
PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

Author: Swart, Marelize ; Whitehorn, Heather ; Ren, Yuan ; Smith, Peter ; Ramesar, Rajkumar ; Dandara, Collet Date: 2012 BACKGROUND: This study investigated variation in NR1I2 and NR1I3 and its effect on plasma efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led research on identifying causative variants in drug metabolising ... Read more c b
Role of antiretroviral therapy exposure host genetics on cytomegalovirus infection status and association with gut microbiome profiles among pregnant black African women

Author: Mhandire, Doreen Zvipo Date: 2020 Cytomegalovirus (CMV) is an important antenatal infection that is prevalent in the developing world. The disabling and potentially fatal effects of CMV acquisition or reactivation during pregnancy on the developing foetus and or neonate are ... Read more
The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer

Author: Ross-Innes, Caryn Sarah Date: 2007 Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development ... Read more
Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana

Author: Torniainen, Suvi ; Parker, M Iqbal ; Holmberg, Ville ; Lahtela, Elisa ; Dandara, Collet ; Jarvela, Irma Date: 2009 BACKGROUND:Lactase non-persistence is a condition where lactase activity is decreased in the intestinal wall after weaning. In European derived populations a single nucleotide polymorphism (SNP) C/T-13910 residing 13.9 kb upstream from the ... Read more c b
Significance of connexion genes in non-syndromic deafness in Africans

Author: Bosch, Jason Date: 2013 Includes abstract. Includes bibliographical references. Read more
The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population

Author: Cindi, Zinhle Date: 2018 Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association ... Read more
The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1

Author: Makambwa, Edson Date: 2019 Warfarin, the most commonly prescribed anticoagulant, is principally metabolized by cytochrome P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 ... Read more
Type 2 diabetes mellitus and dyslipidaemia: effects of genetic variation in African populations

Author: Tanyanyiwa, Donald Moshen Date: 2018 Background: Low-density lipoproteins (LDL) have been associated with damage to the cardiovascular system in patients with type 2 diabetes mellitus (T2DM). These patients are two (2X) to four (4X) times more likely to develop cardiovascular ... Read more
Virus restriction gene variants and their possible role in neurocognitive function in children born to HIV-infected mothers

Author: Mhandire, Kudakwashe Date: 2012 Host genetic variation is an important determinant of HIV infection, disease progression and HIV-associated neurocognitive deficits. However, there is no sufficient knowledge on the role of genetic variants especially among African populations. ... Read more
Whole exome sequencing to investigate genetic variants of non-syndromic hearing impairment in a population of African ancestry

Author: Manyisa, Noluthando Date: 2018 Introduction: Hearing impairment occurs when a child has hearing loss greater than 30dB in their better hearing ear and an adult cannot detect sound lower than 40dB in the better hearing ear. It is a common sensory disorder that affecting ... Read more