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Browsing by Author "Wiesner, Lubbe"

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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites

Author: Redhi, Devasha Date: 2021 The recurring challenge of the emergence of drug resistance necessitates the continual development of improved antimalarial treatments, which can target parasite strains that display reduced susceptibility towards current therapy. Consequently, ... Read more
Antimalarial activity and pharmacokinetic properties of new chemical entities

Author: Dambuza, Ntokozo Shirley Date: 2013 Includes abstract. Includes bibliographical references. Read more
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

Author: Gibhard, Liezl ; Coertzen, Dina ; Reader, Janette ; van der Watt, Mariëtte E ; Birkholtz, Lyn-Marie ; Wong, Ho Ning ; Batty, Kevin T ; Haynes, Richard K ; Wiesner, Lubbe Date: 03 Dec 2021 Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one ... Read more c b
Correction to: Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauf, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 19 Mar 2021 An amendment to this paper has been published and can be accessed via the original article. Read more c b
Determination of biomarkers for toxicity and antiretroviral adherence in hair in South African patients

Author: Johnston, Jenna Date: 2018 Background: Substance abuse is one of the many factors associated with poor levels of antiretroviral adherence and is also prevalent among HIV-infected individuals. Ethyl glucuronide, a minor metabolite of alcohol, is a stable biomarker in ... Read more
Determination of Rifapentine and 25-O-desacetyl Rifapentine from 100 µl human breastmilk by LC-MS/MS using protein precipitation and solid phase extraction

Author: Mkhize, Buyisile Date: 2019 There is currently no information available on the transfer of the second-line anti-TB drug, rifapentine and its metabolite, into breastmilk. The subsequent implications to the breastfed infant, as well as consequences of long-term exposure ... Read more
Determination of total, unbound, and intracellular concentrations of the antiretroviral drugs Efavirenz, Lopinavir, and Ritonavir

Author: Kriegler Foster, Katie Date: 2022 Efavirenz, lopinavir, and ritonavir are antiretroviral drugs used for the treatment of HIV in South Africa. Plasma concentrations of these drugs are routinely monitored to ensure efficacy, minimise adverse effects, and adjust dosing. However, ... Read more
The determination of β-endosulfan and endosulfan sulfate in human serum with dialkylphosphate metabolites as urinary markers using LC-MS/MS electrospray ionization

Author: Bergh, Werner Date: 2017 Two separate bioanalytical methods were developed, validated and applied to determine agricultural exposure to organochlorine and organophosphorus pesticides using different biological matrices as reference sources. The method that was validated ... Read more
Development and validation of liquid chromatography mass spectrometry (L/C/MS/MS) assay for the determination of plasma 4betahydroxycholestrol and cholesterol in HIV infected children in Africa

Author: Ngwalero, Precious Date: 2015 4β-hydroxycholesterol (4β-OHC) is a metabolite of cholesterol formed by Cytochrome (CYP) 3A4/5/7 enzymes. It has recently been proposed as an endogenous biomarker forCYP3A4/5/7 activity. This may be useful in prediction of drug-drug interactions ... Read more
Development and validation of selective and sensitive LC-MS/MS Methods for determination of para-aminosalicyclic acid and cycloserine/terizidone applicable to clinical studies for the treatment of tuberculosis

Author: Smit, Michiel Johannes Date: 2018 A method was validated for the quantification of para-aminosalicylic acid (PAS) in human plasma. The technique consisted of a protein precipitation extraction, followed by high performance liquid chromatography with tandem mass spectrometry ... Read more
Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin

Author: Watson, Daniel J. ; Meyers, Paul R. ; Acquah, Kojo Sekyi ; Dziwornu, Godwin A. ; Barnett, Christopher Bevan ; Wiesner, Lubbe Date: 10 Dec 2021 With drug resistance threatening our first line antimalarial treatments, novel chemotherapeutics need to be developed. Ionophores have garnered interest as novel antimalarials due to their theorized ability to target unique systems found in ... Read more c b
Drug discovery at the site of pulmonary tuberculosis

Author: Tanner, Lloyd Date: 2018 The protracted duration of standard tuberculosis (TB) therapy suggests the inadequacy of current first line TB drugs to eliminate the causative agent Mycobacterium tuberculosis (Mtb). Among multiple potential causes, this may be due to poor ... Read more
Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study

Author: Monera-Penduka, Tsitsi G ; Maponga, Charles C ; Wolfe, Alan R ; Wiesner, Lubbe ; Morse, Gene D ; Nhachi, Charles F B Date: 14 Mar 2017 Background: Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs ... Read more c b
Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model

Author: Abay, Efrem ; van der Westuizen, Jan ; Swart, Kenneth ; Gibhard, Liezl ; Lawrence, Nina ; Dambuza, Ntokozo ; Wilhelm, Anke ; Pravin, Kendrekar ; Wiesner, Lubbe Date: 2015 BACKGROUND: Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. According to the World ... Read more c b
Efficacy and safety of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017

Author: Davlantes, Elizabeth ; Dimbu, Pedro R ; Ferreira, Carolina M ; Florinda Joao, Maria ; Pode, Dilunvuidi ; Félix, Jacinto ; Sanhangala, Edgar ; Andrade, Benjamin N ; dos Santos Souza, Samaly ; Talundzic, Eldin ; Udhayakumar, Venkatachalam ; Owens, Chantelle ; Mbounga, Eliane ; Wiesner, Lubbe ; Halsey, Eric S ; Martins, José F ; Fortes, Filomeno ; Plucinski, Mateusz M Date: 03 Apr 2018 Background The Angolan government recommends three artemisinin-based combinations for the treatment of uncomplicated Plasmodium falciparum malaria: artemether–lumefantrine (AL), artesunate–amodiaquine (ASAQ), and dihydroart ... Read more
Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger

Author: Denoeud-Ndam, Lise ; Dicko, Alassane ; Baudin, Elisabeth ; Guindo, Ousmane ; Grandesso, Francesco ; Diawara, Halimatou ; Sissoko, Sibiri ; Sanogo, Koualy ; Traoré, Seydou ; Keita, Sekouba ; Barry, Amadou ; de Smet, Martin ; Lasry, Estrella ; Smit, Michiel ; Wiesner, Lubbe ; Barnes, Karen I ; Djimde, Abdoulaye A ; Guerin, Philippe J ; Grais, Rebecca F ; Doumbo, Ogobara K ; Etard, Jean-François Date: 24 Oct 2016 Background: Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited information is available on the pharmacokinetic properties of antimalarial ... Read more c b
Isolation and characterisation of antiplasmodial compounds from Xerophyta species and the bioavailability, metabolic and efficacy evaluation of 9-0-acetylhydnocarpin in a mouse model

Author: Wiesner, Lubbe Date: 2008 Includes abstract. Includes bibliographical references (leaves 237-265). Read more
Melamine contamination in nutritional supplements - Is it an alarm bell for the general consumer, athletes, and 'Weekend Warriors'?

Author: Gabriels, Gary ; Lambert, Mike ; Smith, Pete ; Wiesner, Lubbe ; Hiss, Donavon Date: 2015 BACKGROUND: Nutritional supplements are used or experimented with by consumers, notably these are; competitive and recreational athletes of all ages, and 'weekend warriors'. As a consequence the supplement industry has grown to meet the ... Read more c b
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria

Author: Anyorigiya, Thomas Atingane Date: 2017 RATIONALE: The accurate measurement of antimalarial drug concentrations in key target patient groups is essential to ensure optimal dosing for malaria treatment and to distinguish between inadequate drug exposure and antimalarial resistance. ... Read more
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Author: Anyorigiya, Thomas A ; Castel, Sandra ; Mauff, Katya ; Atuguba, Frank ; Ogutu, Bernhards ; Oduro, Abraham ; Dosoo, David ; Asante, Kwaku-Poku ; Owusu-Agyei, Seth ; Dodoo, Alexander ; Hodgson, Abraham ; Binka, Fred ; Workman, Lesley J ; Allen, Elizabeth N ; Denti, Paolo ; Wiesner, Lubbe ; Barnes, Karen I Date: 06 Jan 2021 Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal ... Read more c b

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