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Browsing by Author "Dandara, Collet"

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The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Author: Li, Dongping ; Dandara, Collet ; Parker, M Iqbal Date: 2010 BACKGROUND: The Glutathione S-transferases (GSTs) comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study the effects of polymorphisms in these genes on the risk of developing oesophageal squamous ... Read more c b
9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

Author: Ross, Ian Louis ; Dandara, Collet ; Swart, Marelize ; Lacerda, Miguel ; Schatz, Desmond ; Blom, Dirk Jacobus Date: 2014 BACKGROUND: Addison’s disease (AD) has been associated with an increased risk of cardiovascular disease. Glucocorticoid receptor polymorphisms that alter glucocorticoid sensitivity may influence metabolic and cardiovascular risk factors in ... Read more c b
A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics

Author: Soko, Nyarai D ; Masimirembwa, Collen ; Dandara, Collet Date: 14 Jun 2018 Objective: This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism SLCO1B1 c.1929A>C in genomic DNA samples. The polymorphism SLCO1B1 c.1929A>C has been associated with increased activity ... Read more
APOE, PCSK9, and CETP genetic variants as potential biomarkers of dyslipidaemia in black South Africans with Type 2 Diabetes Mellitus

Author: Evans, Jonathan Date: 2018 Dyslipidaemia is a commonly encountered clinical condition and is a major risk factor for cardiovascular diseases. Although there are many factors associated with dyslipidaemia, a strong genetic component is evident. Apolipoprotein E (APOE), ... Read more
CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Author: Chatterjee, Koushik ; Dandara, Collet ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2010 BACKGROUND: Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but only a small fraction ... Read more c b
Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line

Author: Hassen, Naseeha Date: 2014 Cancer is a leading cause of death worldwide. Oesophageal cancer in particular is the sixth most common cause of cancer deaths globally and its incidence and mortality rates in Southern Africa are among the highest in the world. One of the ... Read more
Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms

Author: Ekrikpo, Udeme Ekpenyong Date: 2019 Background and purpose: With the advent of antiretroviral therapy, HIV-infected individuals now live longer and are at increased risk of chronic kidney disease (CKD). Also, recent studies indicate a genetic predisposition to CKD in the African ... Read more
Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Author: Centner, Chad Date: 2012 Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced ... Read more
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

Author: Chatterjee, Koushik ; Engelmark, Malin ; Gyllensten, Ulf ; Dandara, Collet ; Merwe, Lize ; Galal, Ushma ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2009 BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated ... Read more c b
Functional Genome-wide Association Studies (fGWAS) and genomics landscape of signatures of polygenic adaptation in Botswana populations with HIV-1 C infection

Author: Choga, Wonderful Tatenda Date: 2022 The burden of the human immunodeficiency virus subtype (HIV) is catastrophic, especially in Botswana, a nation in Southern Africa, where 20.7% of persons aged 15 to 49 years are living with HIV (PWH). Although HIV exposure rates are extremely ... Read more
Genetic aetiology of autosomal recessive non-syndromic hearing loss in sub-Saharan African patients: evaluation using targeted and whole exome sequencing

Author: Lebeko, Kamogelo Date: 2019 Hearing Loss (HL) is one of the highest contributors to disability worldwide. The highest incidence of the disease is seen in developing countries, such as those in subSaharan Africa (SSA). Patients affected with disabling HL are reported to ... Read more
Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer

Author: Li, Dong-Ping Date: 2008 Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution ... Read more
Genetic variation in toll like receptors 2, 7, 9 and interleukin-6 is associated with cytomegalovirus infection in late pregnancy

Author: Mhandire, Doreen Z ; Mhandire, Kudakwashe ; Magadze, Mulalo ; Wonkam, Ambroise ; Kengne, Andre P ; Dandara, Collet Date: 25 May 2020 Background Maternal cytomegalovirus (CMV) infection and/or reactivation in pregnancy is associated with a myriad of adverse infant outcomes. However, the role of host genetic polymorphisms in modulating maternal CMV status is inconclusive. ... Read more c b
Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome

Author: Wonkam, Ambroise ; Noubiap, Jean ; Bosch, Jason ; Dandara, Collet ; Toure, Genevieve Date: 2013 BACKGROUND: Keratitis-Ichthyosis-Deafness (KID) syndrome (OMIM 148210) is a congenital ectodermal defect that consists of an atypical ichthyosiform erythroderma associated with congenital sensorineural deafness. KID appears to be genetically ... Read more c b
HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy

Author: Van der Watt, Johan J Date: 2013 Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic ... Read more
Investigation of microRNA expression in thyroid carcinoma among South Africa patients

Author: Mokhesi, Neo Date: 2017 Objective: Thyroid cancer affects approximately 298 million people worldwide and the major challenge is reliably distinguishing patients who present with poor prognosis from those who do not. There are genetic markers that have been shown to ... Read more
Leveraging the microbiome in host genome wide association studies

Author: Awany, Denis Date: 2021 Genome-wide association study (GWAS) has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex ... Read more
A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family

Author: Manyisa, Noluthando ; Schrauwen, Isabelle ; de Souza Rios, Leonardo Alves ; Mowla, Shaheen ; Tekendo-Ngongang, Cedrik ; Popel, Kalinka ; Esoh, Kevin ; Bharadwaj, Thashi ; Nouel-Saied, Liz M. ; Acharya, Anushree ; Nasir, Abdul ; Wonkam-Tingang, Edmond ; Kock, Carmen de ; Dandara, Collet ; Leal, Suzanne M. ; Wonkam, Ambroise Date: 06 Nov 2021 Hearing impairment (HI) is a sensory disorder with a prevalence of 0.0055 live births in South Africa. DNA samples from a South African family presenting with progressive, autosomal dominant non-syndromic HI were subjected to whole-exome ... Read more c b
Novel CYP2E1 haplotype identified in a South African cohort

Author: Heathfield, Laura J ; Dalvie, Shareefa ; Kalideen, Kusha ; Dandara, Collet Date: 2014 Alcohol abuse accounts for approximately 2.5 million deaths annually and is the third highest risk factor for disease and disability. Alcohol is metabolised by polymorphic enzymes and the status of an individual with respect to alcohol ... Read more
Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients

Author: Swart, Marelize Date: 2011 Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute ... Read more

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