Browsing by Subject "information content"

Now showing 1 - 3 of 3
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    Open Access
    Information content-based gene ontology semantic similarity approaches: toward a unified framework theory
    (2013) Mazandu, Gaston K; Mulder, Nicola J
    Several approaches have been proposed for computing term information content (IC) and semantic similarity scores within the gene ontology (GO) directed acyclic graph (DAG). These approaches contributed to improving protein analyses at the functional level. Considering the recent proliferation of these approaches, a unified theory in a well-defined mathematical framework is necessary in order to provide a theoretical basis for validating these approaches. We review the existing IC-based ontological similarity approaches developed in the context of biomedical and bioinformatics fields to propose a general framework and unified description of all these measures. We have conducted an experimental evaluation to assess the impact of IC approaches, different normalization models, and correction factors on the performance of a functional similarity metric. Results reveal that considering only parents or only children of terms when assessing information content or semantic similarity scores negatively impacts the approach under consideration. This study produces a unified framework for current and future GO semantic similarity measures and provides theoretical basics for comparing different approaches. The experimental evaluation of different approaches based on different term information content models paves the way towards a solution to the issue of scoring a term’s specificity in the GO DAG.
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    Open Access
    A review of the Knowledge Management Centre of the Economic and Human Development Department, City of Cape Town
    (2012-03) UCT Knowledge Co-op
    The Knowledge Management Centre (KMC) for a municipal department was set up by a Project Consultant in 1998, with the aim of providing a largely self-service resource centre to store and distribute appropriate and up-to-date information linking to economic development and tourism. The aim of the project is briefly to evaluate the current processes of the KMC and to determine whether these continue to address the needs of its present clients and of potential clients within the City of Cape Town municipal services sector, also to establish whether the KMC is suitably lined up with modern information service delivery techniques. This "As is" assessment is compared with current global best practice in Knowledge Management (KM) for information services of a similar scope and kind to identify a "To be" cluster of facilities and services. A gap analysis identifies areas of change, skill acquisition and suitable strategies for closing the gaps.
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    Open Access
    A review of the Knowledge Management Centre: conducted for the Economic and Human Development Department, City of Cape Town
    (2012-07) Underwood, Peter G; Smith, Gretchen
    Following a study of the resources and services of the Knowledge Management Centre (KMC) of the Economic and Human Development Department (EHD) and a survey of a sample of users and potential users, the conclusion is that the KMC is NOT operating in a Knowledge Management mode; it is operating as a small special library, in a demand-driven mode (page 7). Interviews with the sample of users indicate that a Knowledge Management mode of operation would be more appropriate for supporting the work of the EHD (page 9). It is proposed that the two mutually supportive KM initiatives of leveraging information content and the development and utilisation of knowledge communities should form the core of the EHD's KM strategy (page 13). A set of integrated actions are recommended to implement a Knowledge Management Programme and capacitate the KMC at the EHD (pages 15-18). A job description for a post of Knowledge Officer is provided (pages 19-20).