Browsing by Subject "Rheumatoid arthritis (RA)"
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- ItemOpen AccessImpaired energetics and normal myocardial lipids in rheumatoid arthritis and systemic lupus erythematosus: a phosphorous and proton magnetic resonance spectroscopy and cardiovascular magnetic resonance study(BioMed Central Ltd, 2015) Ntusi, Ntobeko; Holloway, Cameron; Francis, Jane; Davis, Anne; Levelt, Eylem; Piechnik, Stefan; Ferreira, Vanessa; Matthews, Paul; Wordsworth, Paul; Karamitsos, Theodoros; Neubauer, StefanRheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) commonly involve the cardiovascular system and are associated with significant morbidity and mortality, driven by cardiovascular inflammation, microvascular and diastolic dysfunction and fibrosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, strain, ischaemia, altered vascular function, perfusion, inflammation and fibrosis; magnetic resonance spectroscopy (MRS) provides further insights into the status of myocardial energetics and lipidosis. To date, there have been no cardiovascular MRS studies in RA and SLE patients. We hypothesised that RA and SLE would be associated with impaired myocardial energetics and lipidosis.
- ItemOpen AccessImpaired myocardial perfusion in rheumatoid arthritis is associated with impaired strain, strain rate, disease activity and myocardial oedema: a cardiovascular magnetic resonance study(BioMed Central Ltd, 2015) Ntusi, Ntobeko; Sever, Emily; Lockey, Joseph; Francis, Jane; Piechnik, Stefan; Ferreira, Vanessa; Matthews, Paul; Wordsworth, Paul; Neubauer, Stefan; Karamitsos, TheodorosRheumatoid arthritis (RA) commonly involves the cardiovascular system, and is associated with significant morbidity and mortality. Mechanisms of cardiovascular disease (CVD) involvement are not fully understood, but cardiovascular inflammation is thought to drive many of the CVD manifestations, including myocardial ischaemia. The clinical utility of CMR first-pass perfusion for assessment of myocardial ischaemia is well-established. The aim of this study was to assess whether RA patients without known epicardial coronary artery disease have evidence of myocardial hypoperfusion.