Browsing by Subject "Pituitary hormones"

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    GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells
    (1988) Wormald, Patricia J; Millar, Robert P
    Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion from cultured human pituitary cells. The establishment of a human pituitary bioassay system has further made possible the investigation of the direct regulatory roles of GnRH and other neuropeptides in man. To date, such studies in man have been performed in vivo and are thus complicated by the simultaneous interactions of numerous modulators.
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    The role of pituitary growth hormone in the regulation of albumin synthesis and catabolism
    (1970) Kernoff, Leslie Maurice; Brock, J.F.
    Some three years ago I availed myself of an opportunity of pursuing a research project in the Department of Medicine at this Medical School. At that time, a long established interest in the study of plasma albumin metabolism was given fresh impetus by the development of techniques which overcame the problem of measuring rates of albumin synthesis and catabolism under conditions of metabolic chonge. Interest in the Department had centred mainly upon the nature of the adaptive changes occurring in albumin metabolism in response to altered dietary protein intake, and by the time I was due to take up my appointment many of these adaptive changes had been clearly defined. The factors mediating these changes however remained unknown.
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    Open Access
    The role of pituitary growth hormone in the regulation of albumin synthesis and catabolism
    (1970) Kernoff, Leslie Maurice; Brock, J.F.
    Some three years ago I availed myself of an opportunity of pursuing a research project in the Department of Medicine at this Medical School. At that time, a long established interest in the study of plasma albumin metabolism was given fresh impetus by the development of techniques which overcame the problem of measuring rates of albumin synthesis and catabolism under conditions of metabolic chonge. Interest in the Department had centred mainly upon the nature of the adaptive changes occurring in albumin metabolism in response to altered dietary protein intake, and by the time I was due to take up my appointment many of these adaptive changes had been clearly defined. The factors mediating these changes however remained unknown.