Browsing by Author "Tongo, M"
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- ItemOpen AccessGenetic characterization of HIV-1 subtype G envelope sequences by single genome analysis(BioMed Central Ltd, 2012) Rene Ghislain, E; Tongo, M; Ngolle, E; Burgers, W; Dorfman, JSubtype G is the sixth most prevalent subtype of HIV-1 and is responsible for an estimated 1,500,000 infections worldwide. Although systematic analyses of a wide range of HIV-1 envelope sequences and neutralization have been performed, subtype G viruses are severely underrepresented in these studies. There is thus an important need to study subtype G envelope sequences and their neutralization capacities.
- ItemOpen AccessThe recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono- and multi-clade epidemics: implications for HIV vaccine design(BioMed Central Ltd, 2012) Zembe, L; Tongo, M; Ebong, E; Ngobe, EM; Williamson, C; Burgers, WThe high level of genetic diversity of HIV-1 poses a major challenge for global vaccine development. Vaccines based on centralized sequences would minimize genetic distances to multiple clades and potentially maximize cross-reactivity. Whether reactivity of these centralized peptide reagents differs in mono- and multi-clade epidemic is unknown.
- ItemOpen AccessRefined identification of neutralization-resistant CRF02_AG viruses and their sensitivity to anti-MPER neutralizing antibodies(BioMed Central Ltd, 2012) Jacob, RA; Abrahams, F; Tongo, M; Schomaker, M; Roux, P; Ngole, E; Burgers, WA; Dorfman, JRThe first antibody-inducing HIV-1 vaccines are unlikely to protect against all HIV-1 isolates. There is thus a danger that a vaccine will select for HIV-1 viruses that are highly resistant to antibody-mediated neutralization. We sought to identify and characterize such viruses.