Browsing by Author "Stutz, H"
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- ItemOpen AccessP19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice(BioMed Central Ltd, 2009) Stutz, H; Powles, R; Shephard, EG; Williamson, AMycobacterium bovis BCG (BCG) has a number of characteristics that give it great potential to act as a vehicle for the delivery of recombinant vaccines. However, its success depends on overcoming the challenges of poor antigen expression levels and genetic instability. Our studies using an optimized mycobacterial shuttle vector which utilizes the Mycobacterium tuberculosis mtrA promoter, induced upon infection of macrophages, and the M. tuberculosis 19 kDa signal sequence may overcome these issues. We have used this system to generate a recombinant BCG (rBCG) expressing HIV-1 subtype C full length Gag or reverse transcriptase (RT).
- ItemOpen AccessA Tet-repressible regulation system in mycobacteria for application to vaccine design(2009) Mayat, Nureen; Stutz, HIncludes abstract. Includes bibliographical references (leaves 116-123).