Browsing by Author "Steenkamp, D J"
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- ItemOpen AccessCharacterization of a unique sulfoxide synthase found in pathogenic trypanosomes(2013) Mashabela, Gabriel Tshwahla Makgotloduwa; Steenkamp, D J; Gammon, David WIncludes abstract. Includes bibliographical references.
- ItemOpen AccessConditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis(2007) Williams, Monique J; Steyn, Lafras M; Steenkamp, D JErgothioneine and mycothiol are the two major low molecular weight thiols present in mycobacteria. The generation of mycothiol-deficient mutants has demonstrated its role in protecting M tuberculosis against oxidative and nitrosative stress. To date, no ergothioneine-deficient mutants have been identified and the role of ergothioneine in mycobacteria remains unknown. The work in this thesis was performed with the aim of better understanding the function of ergothioneine in mycobacteria, by studying its biosynthesis and the conditions affecting its production.
- ItemOpen AccessMycothiol disulfide reductase as a drug target(2010) Mavumengwana, Vuyo Bhongolethu; Steenkamp, D J; Gammon, David WIncludes abstract. Includes bibliographical references (leaves 154-171).