Browsing by Author "Stanfliet, John Christian"

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    Evaluation of serum prolidase activity as a marker for liver fibrosis in suspected liver disease
    (2011) Stanfliet, John Christian; Pillay, Tahir S
    Liver dysfunction is common, often unrecognised and likely to increase in incidence in the population in parallel with the obesity and attendant type 2 diabetes mellitus epidemics. Liver fibrosis is a significant finding in liver pathology as it imparts important clinical staging and prognostic information, is a risk marker of adverse clinical outcome yet, even if advanced, is capable of reversal. Histological examination of liver biopsy material is the reference standard in the assessment of liver fibrosis, but it is impractical to biopsy all patients suspected of having liver disease. Serumprolidase is among novel biomarkers that have been described in diagnosing and/or staging liver fibrosis. This study evaluated the measurement and the diagnostic accuracy of serumprolidase in determining the potential presence and degree of liver fibrosis compared with liver biopsy.
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    Reference intervals for the echocardiographic measurements of the right heart in African school children and adolescents
    (2011) Lemmer, Carolina Elisabet; Mayosi, Bongani M; Engel, Mark E; Stanfliet, John Christian
    Echocardiography is the primary imaging modality for the diagnosis and management of right ventricular (RV) failure.[2-5] Besides aiding in the diagnosis and management of conditions such as arrhythmogenic right ventricular cardiomyopathy, pulmonary embolism, and RV infarction, the echocardiographic evaluation of the right heart plays a critical role in the diagnosis and management of congenital heart diseases where the RV often serves as the main pumping chamber...