Browsing by Author "Revaz-Breton, Melanie"

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    Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection
    (2013) Hurdayal, Ramona; Brombacher, Frank; Revaz-Breton, Melanie
    In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While IL-4 is the main inducer of Th2 responses, paradoxically it has been shown that exogenously administered IL-4 can promote dendritic cell IL-12 production and enhance Th1 development if given early during infection.