Browsing by Author "More, Stuart"

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    A dissection and angiographic study of anatomical variations in the anterior communicating artery complex in a South African sample
    (2024) Madolo, Mbalentle; Mpolokeng, Kentse; Gunston, Geney; More, Stuart
    The anterior communicating artery complex (ACAC) consists of the A1 and A2 segments of the anterior cerebral artery (ACA) and the anterior communicating artery (ACoA). The ACAC is said to be the most frequent site of aneurysms and anterior cerebral circulation variations. Clear correlation between cerebral arterial circulation variations and aneurysm development has been reported. Cerebrovascular diseases play a significant role in the causes of morbidity in South Africa. South African data in this area of research is currently lacking and thus more knowledge is needed. This study aims to report the prevalence of variations in the ACAC and their link to the prevalence of cerebral aneurysms. For the dissection portion of this study, a total of 68 (35 female and 33 male) adult formalin fixed brains were included. These brains were from the bodies that were previously dissected in the Department of Human Biology, University of Cape Town by the medical undergraduate and honours post-graduate students. For the ang
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    Differences in Tumour Aggressiveness Based on Molecular Subtype and Race Measured by [18F]FDG PET Metabolic Metrics in Patients with Invasive Carcinoma of the Breast
    (Multidisciplinary Digital Publishing Institute, 2023-06-14) Abubakar, Sofiullah; More, Stuart; Tag, Naima; Olabinjo, Afusat; Isah, Ahmed; Lawal, Ismaheel
    Breast cancer in women of African descent tends to be more aggressive with poorer prognosis. This is irrespective of the molecular subtype. [18F]FDG PET/CT metrics correlate with breast cancer aggressiveness based on molecular subtype. This study investigated the differences in [18F]FDG PET/CT metrics of locally advanced invasive ductal carcinoma (IDC) among different racial groups and molecular subtypes. Qualitative and semiquantitative readings of [18F]FDG PET/CT acquired in women with locally advanced IDC were performed. Biodata including self-identified racial grouping and histopathological data of the primary breast cancer were retrieved. Statistical analysis for differences in SUVmax, MTV and TLG of the primary tumour and the presence of regional and distant metastases was conducted based on molecular subtype and race. The primary tumour SUVmax, MTV, TLG and the prevalence of distant metastases were significantly higher in Black patients compared with other races (p < 0.05). The primary tumour SUVmax and presence of distant metastases in the luminal subtype and the primary tumour SUVmax and TLG in the basal subtype were significantly higher in Black patients compared with other races (p < 0.05). The significantly higher PET parameters in Black patients with IDC in general and in those with luminal and basal carcinoma subtypes suggest a more aggressive disease phenotype in this race.