Browsing by Author "Malherbe, F"

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    Nodal disease predicts recurrence whereas other traditional factors affect survival in a cohort of South African patients with differentiated thyroid carcinoma
    (BioMed Central, 2018-11-19) Robertson, B; Parker, M; Shepherd, L; Panieri, E; Cairncross, L; Malherbe, F; Ross, I L; Omar, F; Hunter, A
    Background and aim Information on patients with differentiated thyroid carcinoma in South Africa is limited. The objective of this study was to review demographics and tumour characteristics in a cohort of patients with differentiated thyroid carcinoma, presenting to Groote Schuur Hospital and evaluate risk factors for recurrence and survival. Patients and methodology Retrospective demographic and clinical data were collected on all patients referred between January 2003 and December 2013. Prognostic factors for recurrence free survival and cancer specific survival were assessed using univariate and multivariate analyses. Results The total number of patients was 231.The median age at presentation was 44 years and 82% were female patients. The pathological sub-types were papillary (60.6%), follicular (38.9%) and poorly differentiated (0.5%). Total thyroidectomy was performed in 191 patients and 30 patients required neck dissections. A total of 171 (74%) patients received 131Iodine. The recurrence free and cause specific survival rates at 10 years were 83 and 91%, respectively. Nodal disease at presentation was the only significant risk factor for recurrence (p <  0.001) on multivariate analysis. Significant risk factors for cause specific mortality were age ≥ 45 years (p = 0.006), follicular pathology (p = 0.004), extra-thyroid extension (p = 0.013) and residual tumour (p = 0.004). Conclusions Consistent with international trends, patients with differentiated thyroid carcinoma treated at Groote Schuur Hospital had a favourable prognosis. The known risk factors associated with recurrence and survival in this South African cohort were consistent with those reported in developed countries.
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    The University of Cape Town General Surgery Textbook for Undergraduates
    (University of Cape Town, 2015-06-09) Khan, D; Malherbe, F
    The University of Cape Town General Surgery Textbook for Undergraduates was initially put together by Professor John Terblanche over 26 years ago. It has gone through many updates since to keep pace with the ever changing surgical field. Most recently updated last year this book draws on contributions from many of the surgeons who have worked in, or are still working in the Department of General Surgery at the University of Cape Town. This latest version has been put together by Dr Francois Malherbe under the tenure of Professor Delawir Kahn.