Browsing by Author "Mabizela, Nontobeko"

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    Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation
    (2006) Mabizela, Nontobeko; Rodgers, Allen; Sturrock, Edward D
    Approximately 12 % of males in the Western world are likely to suffer at least one kidney stone in their life. The incidence of kidney stone disease in South Africa is similar in white males; however stone occurrence in the South African black population is extremely rare. The difference between the incidences of kidney stones in the black and white populations in South Africa is unexplained. In general, the role of several urinary proteins in the pathogenesis of this disease has been established. Bikunin is an example. The primary aim of this study was to isolate bikunin from the urine of healthy black and white male subjects and to investigate whether the protein from the black group is a more powerful inhibitor of CaOx crystallization than that from the stone prone white group.
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    Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
    (2003) Mabizela, Nontobeko; Chibale, Kelly
    Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate.