Browsing by Author "Lacerda, Lydia"

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    Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning
    (2010) Lacerda, Lydia; Lecour, Sandrine
    Ischaemic postconditioning (IPostC) is a powerful protective mechanism that activates prosurvival intrinsic signalling cascades to limit reperfusion injury but the exact signalling pathway involved in this cardioprotective effect still remains unclear.
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    Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
    (2005) Lacerda, Lydia; Lecour, Sandrine; Opie, Lionel H
    Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria.