Browsing by Author "Karim, S"

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    Open Access
    Beneficial HLA-mediated viral polymorphisms on the transmitted virus additively influence disease progression in HIV-1, subtype C infection
    (BioMed Central Ltd, 2012) Ntale, R S; Chopera, D R; Ngandu, N K; Abrahams, M; Debra, A; Mlotswa, M; Werner, L; Woodman, Z; Mlisana, K; Karim, S; Gray, CM; Williamson, C; CAPRISA 002 AI Study Team
    Transmitted viral factors have been shown to affect disease progression but whether infection with viruses carrying beneficial HLA-mediated escape polymorphisms affects disease progression in HLA-mismatched participants remains controversial.
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    Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses
    (BioMed Central Ltd, 2012) Riou, C; Abrahams, M; Mlisana, K; Koup, R; Roederer, M; Karim, S; de Bruyn, G; Williamson, C; Gray, CM; Burgers, WA
    The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it remains unclear whether the maintenance of polyfunctionality is linked to particular phenotypic characteristics of the cell, such as the differentiation stage of memory T cells. The goal of this study was to investigate the relationship between the memory maturation stage and polyfunctional profiles of antigen-specific CD8+ T cells.