Browsing by Author "Human, Paul"
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- ItemOpen AccessThe compounding effects of obesity on the development of Intimal Hyperplasia following vascular intervention : a histopathological analysis(2009) Black, Melanie Kim; Human, PaulThis study examines the histopathological response to injury following both balloon angioplasty and endovascular stenting in the Zucker rat, a model that allows interpretation of the role of obesity as well as progressive glucose intolerance and hyperinsulimaemia. Lean and obese Zucker fatty rats and Zucker diabetic fatty rat (ZDF) were subjected to balloon injury with or without stenting. The development of IH, along with the histological response to injury was analyzed.
- ItemOpen AccessEarly calcification patterns of bioprosthetic aortic tissue : a comparison of amino versus carboxyl group and combination cross-linked tissue(2003) Han, Richard I-Ming; Human, Paul
- ItemOpen AccessMitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking(2009) Du Plessis, Engela Helena; Human, PaulThis research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking antigens to mitigate the inflammatory response is needed.
- ItemOpen AccessSixteen year retrospective analysis of rheumatic and non-rheumatic heart disease patients undergoing valve procedures at Groote Schuur Hospital first incidence single aortic and mitral valve replacement(2012) Ogunrombi, Akinwumi Babatunde; Human, PaulRheumatic heart disease is still the most common cause of valvular heart lesions requiring replacement or repair procedures worldwide. In South Africa, where there is an interesting mix of first and third world dynamics, factors sustaining the epidemic of rheumatic disease are still commonplace. The choice of appropriate valve procedure and prosthesis in our setting will depend on an adequate knowledge of short and long term outcomes of valve replacement and repair. The aim of this thesis was to evaluate the demographics and presentation of our rheumatic and non-rheumatic patients and to determine if our current implantation choices could be validated.