Browsing by Author "Hamdulay, Zarina"

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    Phytosterol-enriched margarine substitution in the management of familial hypercholesterolaemia
    (2002) Hamdulay, Zarina; Marais, David; Visser, Marianne
    The primary objective was to substitute phytosterol and regula margarine into the diets of familial hypercholesterolaemia (FH) patients and to investigate whether the phytosterol containing margarine had a cholesterol lowering effect. Another objective was to investigate immune responses to phytosterols. A randomized double-blind cross-over study in which subjects with FH consumed 20g of regular or phytosterol margarine for a period of 6 weeks on each margarine, after which a washout period of 4 weeks was followed. There were 5 visits in total, visit 1 being the collection of baseline data, visit 2 the randomisation to either of the regular of phytosterol margarine periods, visit 3 for the cross-ver to the alternative margarine form, visit 4 marked the onset of washout period and visit 5, was the last evaluation visit. Margarine use was in addition to current, albeit limite, pharmacological treatment with statins.