Browsing by Author "Hamann, A R"

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    Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum
    (South African Chemical Institute, 2013) Hamann, A R; de Kock, C; Smith, P J; van Otterlo, W A; Blackie, M A
    Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration.