Browsing by Author "Chukwujekwu, J. C."

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    Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata
    (2009) Chukwujekwu, J. C.; Lategan, C. A.; Smith, P. J.; Van Heerden, F. R.; Van Staden, J.
    Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds — vernolide (IC50 = 1.87 μg/ml) and vernodalin (IC50 = 0.52 μg/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites.