Browsing by Author "Chapman, R"

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    Impacts, vulnerability and adaptation in key South African sectors: an input into the Long Term Mitigation Scenarios process.
    (Energy Research Centre, University of Cape Town, 2007) Midgley, G; Chapman, R; Mukheibir, P; Tadross, M; Hewitson, B; Wand, S; Schulze, R; Lumsden, T; Horan, M; Warburton, M; Kgope, B; Mantlana, B; Knowles, A; Abayomi, A; Ziervogel, G; Cullis, R; Theron, A
    Ten free-standing chapters make up this report, and this Executive Summary and supporting Synthesis Report serve to draw together the main findings in both an abbreviated and an extended and illustrated format that focuses on main findings, but also adds a level of detail for the purpose of communicating the key results, and the uncertainties associated with them, for the benefit of a policy maker. The chapters that make up this report are compiled as separate documents as follows. These are generally reviews of the literature available, but in some cases comprise new work that has been carried out to provide information in an area that is lacking an assessment.
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    A pantothenate suxotroph of BCG rxpressing Gag confers enhanced HIV-specific immunogenicity compared to wildtype and perfingolysin expressing strains
    (BioMed Central Ltd, 2012) Chetty, S; Shephard, E; Bowers, D; Darby, M; Horsnell, W; Chapman, R; Williamson, A
    In tuberculosis vaccine studies, perfingolysin expressing strains (pfo) of recombinant Mycobacterium bovis (rBCG) have been shown to enhance immunogenicity as compared to wildtype strains whilst pantothenate auxotrophic strains (ΔpanCD) have been shown to be safer and more immunogenic. Our group has recently shown that rBCGΔpanCD expressing HIV-1 Gag is more immunogenic than the wildtype Pasteur strain of BCG in the murine model. In this study, a wild type strain, a ΔpanCDstrain, a pfo strain and a ΔpanCD strain expressing perfringolysin (ΔpanCDpfo) of Danish BCG were used as vectors to express HIV-1 subtype C Gag. Gag specific immune responses induced by a prime with each rBCG-Gag vaccine and boost with modified vaccinia Ankara (MVA) were compared.
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    A prime-boost immunization with rBCG expressing HIV-1 Gag, RT and gp120 and SAAVI MVA-C elicits immune responses in blood and MALT of rhesus macaques
    (BioMed Central Ltd, 2012) Chege, GK; Chapman, R; Shephard, EG; Williamson, A
    CG pantothenate auxtroph (ΔpanCD) is safer to use as a live vaccine vector than wild-type BCG. We constructed 3 recombinant BCGΔpanCD candidate vaccines expressing HIV-1 subtype C Gag, RT and Env (gp120). The current study investigated immune responses in rhesus macaques following a prime with a mixture of these rBCG vaccines and a boost with SAAVI MVA-C (MVA).
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    Social development for the Cape Flats: an alternative planning structure
    (1975) Paton, Hugh M; Chapman, R
    An initial analysis into the present problems which will affect the future growth of the Western Cape resulted in the conclusion that the situation of the Coloured population is the factor most urgently requiring positive planning resolutions. Understanding the area's problems leads one to conclude that the main thrusts must be directed towards increased opportunities for the residents to fulfil their potential, and towards a greater involvement in the decisions made about their future. The arrangement of the thesis was thus developed around the three interrelated notions of administrative structure, human resources and social development, physical and economic resources. An unbound 'process diagram’ is provided in the back cover to facilitate an understanding of the sequence adopted. The administrative and planning activities of various local authorities, particularly the Cape Town City Council, were investigated with respect to the relationship between their actions and the causes of problems on the Flats. The complexity of social problems necessitated a consideration of the concept and the theory of social development. This was defined as the process whereby the individual and/or group is enabled to increasingly participate in and contribute to the growing flow of social transactions over time. By adopting Social Development as the goal for the Cape Flats and developing objectives for its six primary subsystems (housing, education, employment, recreation, community and civic), the subsequent form of the thesis was established.