Browsing by Author "Burgers, W"

Now showing 1 - 3 of 3
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    Genetic characterization of HIV-1 subtype G envelope sequences by single genome analysis
    (BioMed Central Ltd, 2012) Rene Ghislain, E; Tongo, M; Ngolle, E; Burgers, W; Dorfman, J
    Subtype G is the sixth most prevalent subtype of HIV-1 and is responsible for an estimated 1,500,000 infections worldwide. Although systematic analyses of a wide range of HIV-1 envelope sequences and neutralization have been performed, subtype G viruses are severely underrepresented in these studies. There is thus an important need to study subtype G envelope sequences and their neutralization capacities.
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    Open Access
    The recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono- and multi-clade epidemics: implications for HIV vaccine design
    (BioMed Central Ltd, 2012) Zembe, L; Tongo, M; Ebong, E; Ngobe, EM; Williamson, C; Burgers, W
    The high level of genetic diversity of HIV-1 poses a major challenge for global vaccine development. Vaccines based on centralized sequences would minimize genetic distances to multiple clades and potentially maximize cross-reactivity. Whether reactivity of these centralized peptide reagents differs in mono- and multi-clade epidemic is unknown.
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    A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination
    (BioMed Central Ltd, 2012) Chege, GK; Burgers, W; Muller, T; Shephard, EG; Williamson, C; Williamson, A
    We have previously reported induction of robust immune responses in rhesus macaques following a prime boost immunization with candidate HIV-1 vaccines, SAAVI DNA-C (DNA) and SAAVI MVA-C (MVA). These vaccines are already in clinical evaluation. In the current study, we investigated whether re-boosting these animals with a single MVA inoculation after more than 3 years was sufficient to restore previous magnitudes of HIV-specific immune responses.