Browsing by Author "Adeola, Henry A"

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    “Next generation sequencing identifies mutations in GNPTG gene as a cause of familial form of scleroderma-like disease”
    (BioMed Central, 2017-12-29) Arowolo, Afolake T; Adeola, Henry A; Khumalo, Nonhlanhla P
    A letter to the editor making some recommendations on the article entitled “Next generation sequencing identifies mutations in GNPTG gene as a cause of familial form of scleroderma-like disease”.
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    Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa
    (BioMed Central, 2017-06-05) Adeola, Henry A; Soyele, Olujide O; Adefuye, Anthonio O; Jimoh, Sikiru A; Butali, Azeez
    Background: The completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have contributed immensely to individualized/personalized medicine in the developed world. Main body: At the dawn of precision medicine, various omics-based therapies and bioengineering can now be applied accurately for the diagnosis, prognosis, treatment, and risk stratifcation of cancer in a manner that was hitherto not thought possible. The widespread introduction of genomics and other omics-based approaches into the postgraduate training curriculum of diverse medical and dental specialties, including pathology has improved the profciency of practitioners in the use of novel molecular signatures in patient management. In addition, intricate details about disease disparity among diferent human populations are beginning to emerge. This would facilitate the use of tailor-made novel theranostic methods based on emerging molecular evidences. Conclusion: In this review, we examined the challenges and prospects of using currently available omics-based technologies vis-à-vis oral pathology as well as prompt cancer diagnosis and treatment in a resource limited setting.
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    Phytodentistry in Africa: prospects for head and neck cancers
    (2021-02-05) Adeola, Henry A; Sabiu, Saheed; Aruleba, Raphael T; Adekiya, Tayo A; Adefuye, Anthonio O; Adefuye, Ogheneochuko J; Oyinloye, Babatunji E
    Background Orthodox dentistry has undergone significant changes in recent times with the introduction of various omics and molecular targeted therapies both at the experimental/trial and clinical implementation level. Although, significant milestones have been achieved in the molecular dentistry field in the past decade, there remains a dearth of application of phytopharmacological innovation in personalized and targeted therapies for dental diseases. Main body From time immemorial, plant products have long been an integral aspect of dental practice ranging from chewing sticks/herbal kinds of toothpaste to dental/impression materials. The current era of precision medicine seeks to apply a multipronged molecular and bio-computational approaches to solve fundamental medical problems that have hitherto remained difficult. Remarkable changes in the molecular/omics era, have transformed empirical therapies into personalized/individualized ones. Furthermore, the combinatorial application and the widespread introduction of high-throughput molecular tools such as pharmacogenomics, phytopharmacology, metabolomics, mathematical modelling, and genetic engineering inter alia, has tremendously improved the diagnostic and therapeutic landscape of medicine. Additionally, the variable molecular epidemiology of diseases among different population and emerging molecular evidence warrants the use of customized novel theranostic techniques. Unfortunately, the footprint of such emerging application is sparse in dental diseases such as maxillofacial cancers. Conclusion Hence, this review seeks to evaluate the potential application of phytopharmacological approaches to head and neck cancers in a resource-limited environment, such as Africa.