Browsing by Author "Abera, Aron"

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    Dikakapa everday heroes - African journeys to success
    (2013) Xulu, Khethelo; Kiravu, Agano; Nofemela, Andile; Ndlovu, Hlumani; Moholisa, Retsilisitsoe; Abera, Aron
    This book, Dikakapa Everyday Heroes: African journeys to success, is the proud initiative of a social intervention project called Dikakapa: Every-day Heroes. "Dikakapa Everyday Heroes: African journeys to success" is a collection of short personal stories by young Africans. In the book, the authors exercise self introspection and examination to reflect on how they navigated the formal education system (matric and/or tertiary level) to emerge as winners in their chosen career paths. It is a motivational tool for those aspiring to join tertiary institutions and is an invaluable resource for new university entrants who often struggle to balance their new found independence with the demands and discipline that varsity requires.
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    The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
    (2005) Abera, Aron; Henderson, Howard; Marais, A David
    Monogenic defects in the low density lipoprotein (LDL) uptake pathway occur commonly in South Africans, particularly in the Afrikaner community where inheritance is typically autosomal dominant, arising predominantly from abnormal structure and thus function of the LDL receptor (LDLr). Defects in LDLr binding domain of apolipopreteinB-100 (apoB-100) are rarely encountered and are know as Familial defective apoB-100 (FDB). Several critical proteins are active in the LDL uptake pathway and their deficiencies are now being shown to underlie the rare autosomal recessive forms of hypercholesterolemia (ARH). One of these proteins is the LDLr adaptor protein know as ARH, which is presumed to facilitate interaction of the cytoplasmic tail of the LDLr with the internal protein matrix required for the receptor internalisation.