Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women

Simple item page
dc.contributor.authorMbulawa, Zizipho Z
dc.contributor.authorJohnson, Leigh F
dc.contributor.authorMarais, Dianne J
dc.contributor.authorGustavsson, Inger
dc.contributor.authorMoodley, Jennifer R
dc.contributor.authorCoetzee, David
dc.contributor.authorGyllensten, Ulf
dc.contributor.authorWilliamson, Anna-Lise
dc.date.accessioned2015-07-30T04:01:42Z
dc.date.available2015-07-30T04:01:42Z
dc.date.issued2014-01-31
dc.date.updated2015-01-15T17:52:40Z
dc.description.abstractAbstract Background Persistent high-risk (HR) human papillomavirus (HPV) infection and increased HR-HPV viral load are associated with the development of cancer. This study investigated the effect of human immunodeficiency virus (HIV) co-infection, HIV viral load and CD4 count on the HR-HPV viral load; and also investigated the predictors of cervical abnormalities. Methods Participants were 292 HIV-negative and 258 HIV-positive women. HR-HPV viral loads in cervical cells were determined by the real-time polymerase chain reaction. Results HIV-positive women had a significantly higher viral load for combined alpha-9 HPV species compared to HIV-negative women (median 3.9 copies per cell compared to 0.63 copies per cell, P = 0.022). This was not observed for individual HPV types. HIV-positive women with CD4 counts >350/μl had significantly lower viral loads for alpha-7 HPV species (median 0.12 copies per cell) than HIV-positive women with CD4 ≤350/μl (median 1.52 copies per cell, P = 0.008), but low CD4 count was not significantly associated with increased viral load for other HPV species. High viral loads for alpha-6, alpha-7 and alpha-9 HPV species were significant predictors of abnormal cytology in women. Conclusion HIV co-infection significantly increased the combined alpha-9 HPV viral load in women but not viral loads for individual HPV types. High HR-HPV viral load was associated with cervical abnormal cytology.
dc.identifier.apacitationMbulawa, Z. Z., Johnson, L. F., Marais, D. J., Gustavsson, I., Moodley, J. R., Coetzee, D., ... Williamson, A. (2014). Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women. <i>BMC Infectious Diseases</i>, http://hdl.handle.net/11427/13615en_ZA
dc.identifier.chicagocitationMbulawa, Zizipho Z, Leigh F Johnson, Dianne J Marais, Inger Gustavsson, Jennifer R Moodley, David Coetzee, Ulf Gyllensten, and Anna-Lise Williamson "Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women." <i>BMC Infectious Diseases</i> (2014) http://hdl.handle.net/11427/13615en_ZA
dc.identifier.citationMbulawa, Z. Z., Johnson, L. F., Marais, D. J., Gustavsson, I., Moodley, J. R., Coetzee, D., ... & Williamson, A. L. (2014). Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women. BMC infectious diseases, 14(1), 51.
dc.identifier.ris TY - Journal Article AU - Mbulawa, Zizipho Z AU - Johnson, Leigh F AU - Marais, Dianne J AU - Gustavsson, Inger AU - Moodley, Jennifer R AU - Coetzee, David AU - Gyllensten, Ulf AU - Williamson, Anna-Lise AB - Abstract Background Persistent high-risk (HR) human papillomavirus (HPV) infection and increased HR-HPV viral load are associated with the development of cancer. This study investigated the effect of human immunodeficiency virus (HIV) co-infection, HIV viral load and CD4 count on the HR-HPV viral load; and also investigated the predictors of cervical abnormalities. Methods Participants were 292 HIV-negative and 258 HIV-positive women. HR-HPV viral loads in cervical cells were determined by the real-time polymerase chain reaction. Results HIV-positive women had a significantly higher viral load for combined alpha-9 HPV species compared to HIV-negative women (median 3.9 copies per cell compared to 0.63 copies per cell, P = 0.022). This was not observed for individual HPV types. HIV-positive women with CD4 counts >350/μl had significantly lower viral loads for alpha-7 HPV species (median 0.12 copies per cell) than HIV-positive women with CD4 ≤350/μl (median 1.52 copies per cell, P = 0.008), but low CD4 count was not significantly associated with increased viral load for other HPV species. High viral loads for alpha-6, alpha-7 and alpha-9 HPV species were significant predictors of abnormal cytology in women. Conclusion HIV co-infection significantly increased the combined alpha-9 HPV viral load in women but not viral loads for individual HPV types. High HR-HPV viral load was associated with cervical abnormal cytology. DA - 2014-01-31 DB - OpenUCT DO - 10.1186/1471-2334-14-51 DP - University of Cape Town J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women TI - Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women UR - http://hdl.handle.net/11427/13615 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13615
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2334-14-51
dc.identifier.vancouvercitationMbulawa ZZ, Johnson LF, Marais DJ, Gustavsson I, Moodley JR, Coetzee D, et al. Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women. BMC Infectious Diseases. 2014; http://hdl.handle.net/11427/13615.en_ZA
dc.language.rfc3066en
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderMbulawa et al.; licensee BioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/2.0*
dc.sourceBMC Infectious Diseasesen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcinfectdis/
dc.subject.otherHuman papillomavirusen_ZA
dc.subject.otherHuman immunodeficiency virusen_ZA
dc.subject.otherViral loaden_ZA
dc.titleIncreased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Mbulawa_Increased_alpha-9_2014.pdf
Size:
189.41 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles